A phenotype for the α7 nicotinic acetylcholine receptor null mutant

Barbara J Morley, Jorge F. Rodriguez-Sierra

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes. The null mutant mouse is viable and generally normal. Here, we report a phenotype for the α7 nAChR null mutant mouse. The α7 nAChR is obligatory for the synchronization of an important biological rhythm, the female estrous cycle. The female null mutant mouse has asynchronous estrous cycles and a reduced number of surviving pups. Female null mutants also demonstrate a reliable diversity in phenotype, suggesting an interaction between environment and gene expression. Real-time RT-PCR measurements of the α7 mRNA expression in reproductive tissues of wild-type mice suggest that the ovulatory dysfunction in null mutants is probably central in origin.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalBrain Research
Volume1023
Issue number1
DOIs
StatePublished - Oct 8 2004

Fingerprint

Nicotinic Receptors
Phenotype
Estrous Cycle
Periodicity
Real-Time Polymerase Chain Reaction
Gene Expression
Messenger RNA
Brain

Keywords

  • Endocrine
  • Mouse
  • Phenotype
  • α7 Nicotinic acetylcholine receptor

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A phenotype for the α7 nicotinic acetylcholine receptor null mutant. / Morley, Barbara J; Rodriguez-Sierra, Jorge F.

In: Brain Research, Vol. 1023, No. 1, 08.10.2004, p. 41-47.

Research output: Contribution to journalArticle

Morley, Barbara J ; Rodriguez-Sierra, Jorge F. / A phenotype for the α7 nicotinic acetylcholine receptor null mutant. In: Brain Research. 2004 ; Vol. 1023, No. 1. pp. 41-47.
@article{1babff74dadc4854a7ef757b189c891f,
title = "A phenotype for the α7 nicotinic acetylcholine receptor null mutant",
abstract = "The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes. The null mutant mouse is viable and generally normal. Here, we report a phenotype for the α7 nAChR null mutant mouse. The α7 nAChR is obligatory for the synchronization of an important biological rhythm, the female estrous cycle. The female null mutant mouse has asynchronous estrous cycles and a reduced number of surviving pups. Female null mutants also demonstrate a reliable diversity in phenotype, suggesting an interaction between environment and gene expression. Real-time RT-PCR measurements of the α7 mRNA expression in reproductive tissues of wild-type mice suggest that the ovulatory dysfunction in null mutants is probably central in origin.",
keywords = "Endocrine, Mouse, Phenotype, α7 Nicotinic acetylcholine receptor",
author = "Morley, {Barbara J} and Rodriguez-Sierra, {Jorge F.}",
year = "2004",
month = "10",
day = "8",
doi = "10.1016/j.brainres.2004.07.006",
language = "English (US)",
volume = "1023",
pages = "41--47",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - A phenotype for the α7 nicotinic acetylcholine receptor null mutant

AU - Morley, Barbara J

AU - Rodriguez-Sierra, Jorge F.

PY - 2004/10/8

Y1 - 2004/10/8

N2 - The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes. The null mutant mouse is viable and generally normal. Here, we report a phenotype for the α7 nAChR null mutant mouse. The α7 nAChR is obligatory for the synchronization of an important biological rhythm, the female estrous cycle. The female null mutant mouse has asynchronous estrous cycles and a reduced number of surviving pups. Female null mutants also demonstrate a reliable diversity in phenotype, suggesting an interaction between environment and gene expression. Real-time RT-PCR measurements of the α7 mRNA expression in reproductive tissues of wild-type mice suggest that the ovulatory dysfunction in null mutants is probably central in origin.

AB - The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes. The null mutant mouse is viable and generally normal. Here, we report a phenotype for the α7 nAChR null mutant mouse. The α7 nAChR is obligatory for the synchronization of an important biological rhythm, the female estrous cycle. The female null mutant mouse has asynchronous estrous cycles and a reduced number of surviving pups. Female null mutants also demonstrate a reliable diversity in phenotype, suggesting an interaction between environment and gene expression. Real-time RT-PCR measurements of the α7 mRNA expression in reproductive tissues of wild-type mice suggest that the ovulatory dysfunction in null mutants is probably central in origin.

KW - Endocrine

KW - Mouse

KW - Phenotype

KW - α7 Nicotinic acetylcholine receptor

UR - http://www.scopus.com/inward/record.url?scp=4444294043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444294043&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2004.07.006

DO - 10.1016/j.brainres.2004.07.006

M3 - Article

VL - 1023

SP - 41

EP - 47

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -