A PET investigation of implicit and explicit sequence learning

Scott L. Rauch, Cary R Savage, Halle D. Brown, Tim Curran, Nathaniel M. Alpert, Adair Kendrick, Alan J. Fischman, Stephen M. Kosslyn

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

The purpose of this study was to determine the mediating neuroanatomy of implicit and explicit sequence learning using a modified version of the serial reaction time (SRT) paradigm. Subjects were seven healthy, right‐handed adults (three male, four female, mean age 26.7, range 18–43 yr). PET data were acquired via the oxygen‐15‐labeled‐carbon dioxide inhalation method while subjects performed the SRT. Subjects were scanned during two blocks each of (1) no sequence (Random), (2) single‐blind, 12‐item sequence (Implicit), and (3) unblinded, same sequence (Explicit). Whole‐brain‐normalized images reflecting relative regional cerebral blood flow (rCBF) were transformed to Talairach space, and statistical parametric maps (SPMs) of z‐scores were generated for comparisons of interest. The threshold for significant activation was defined as z‐score ≥ 3.00. Behavioral data demonstrated significant learning (P < .05) for Implicit and Explicit conditions. Tests of explicit knowledge reflected non‐significant explicit contamination during the Implicit condition. Foci of significant activation in the Implicit condition were found in right ventral premotor cortex, right ventral caudate/nucleus accumbens, right thalamus, and bilateral area 19; activation in the Explicit condition included primary visual cortex, peri‐sylvian cortex, and cerebellar vermis. Activations in visual and language areas during the Explicit condition may reflect conscious learning strategies including covert verbal rehearsal and visual imagery. Right‐sided premotor, striatal, and thalamic activations support the notion that implicit sequence learning is mediated by cortico‐striatal pathways, preferentially within the right hemisphere. © 1996 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)271-286
Number of pages16
JournalHuman Brain Mapping
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1995

Fingerprint

Learning
Reaction Time
Cerebrovascular Circulation
Corpus Striatum
Neuroanatomy
Caudate Nucleus
Imagery (Psychotherapy)
Regional Blood Flow
Nucleus Accumbens
Motor Cortex
Visual Cortex
Thalamus
Inhalation
Language
Cerebellar Vermis

Keywords

  • memory
  • premotor cortex
  • striatum

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Rauch, S. L., Savage, C. R., Brown, H. D., Curran, T., Alpert, N. M., Kendrick, A., ... Kosslyn, S. M. (1995). A PET investigation of implicit and explicit sequence learning. Human Brain Mapping, 3(4), 271-286. https://doi.org/10.1002/hbm.460030403

A PET investigation of implicit and explicit sequence learning. / Rauch, Scott L.; Savage, Cary R; Brown, Halle D.; Curran, Tim; Alpert, Nathaniel M.; Kendrick, Adair; Fischman, Alan J.; Kosslyn, Stephen M.

In: Human Brain Mapping, Vol. 3, No. 4, 01.01.1995, p. 271-286.

Research output: Contribution to journalArticle

Rauch, SL, Savage, CR, Brown, HD, Curran, T, Alpert, NM, Kendrick, A, Fischman, AJ & Kosslyn, SM 1995, 'A PET investigation of implicit and explicit sequence learning', Human Brain Mapping, vol. 3, no. 4, pp. 271-286. https://doi.org/10.1002/hbm.460030403
Rauch SL, Savage CR, Brown HD, Curran T, Alpert NM, Kendrick A et al. A PET investigation of implicit and explicit sequence learning. Human Brain Mapping. 1995 Jan 1;3(4):271-286. https://doi.org/10.1002/hbm.460030403
Rauch, Scott L. ; Savage, Cary R ; Brown, Halle D. ; Curran, Tim ; Alpert, Nathaniel M. ; Kendrick, Adair ; Fischman, Alan J. ; Kosslyn, Stephen M. / A PET investigation of implicit and explicit sequence learning. In: Human Brain Mapping. 1995 ; Vol. 3, No. 4. pp. 271-286.
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