A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders

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15 Citations (Scopus)

Abstract

Aberrant innate and adaptive immune responses are neurodegenerative disease effectors. Disease is heralded by a generalized, but subtle immune activation orchestrated by the release of extracellular prion-like aggregated and oxidized or otherwise modified proteins. These are responsible for an inflammatory neurotoxic cascade. The perpetrators of such events include effector T cells and activated microglia. What ensues are Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis and stroke with changed frequencies of effector T cell and reduced numbers or function of regulatory lymphocytes. The control of such immune responses could lead to new therapeutic strategies and the means to effectively combat a composite of diseases that have quite limited therapeutic options.

Original languageEnglish (US)
Pages (from-to)645-650
Number of pages6
JournalJournal of Neuroimmune Pharmacology
Volume10
Issue number4
DOIs
StatePublished - Dec 1 2015

Fingerprint

Adaptive Immunity
Innate Immunity
Neurodegenerative Diseases
T-Lymphocytes
Prions
Amyotrophic Lateral Sclerosis
Microglia
Parkinson Disease
Alzheimer Disease
Cell Count
Stroke
Lymphocytes
Therapeutics
Proteins

Keywords

  • Adaptive immunity
  • Alzheimer’s disease
  • Amyotrophic lateral sclerosis
  • Effector T cells
  • Innate immunity
  • Neurodegenerative diseases
  • Neurodestruction
  • Neuroprotection
  • Parkinson’s disease
  • Regulatory T cells
  • Stroke

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

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abstract = "Aberrant innate and adaptive immune responses are neurodegenerative disease effectors. Disease is heralded by a generalized, but subtle immune activation orchestrated by the release of extracellular prion-like aggregated and oxidized or otherwise modified proteins. These are responsible for an inflammatory neurotoxic cascade. The perpetrators of such events include effector T cells and activated microglia. What ensues are Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis and stroke with changed frequencies of effector T cell and reduced numbers or function of regulatory lymphocytes. The control of such immune responses could lead to new therapeutic strategies and the means to effectively combat a composite of diseases that have quite limited therapeutic options.",
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