A novel technology for hematopoietic stem cell expansion using combination of nanofiber and growth factors

Jingwei Lu, Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Hematopoietic stem cell transplantation has been applied as a standard procedure of treatment for hematological disorders like multiple myeloma and leukemia for several decades. Various sources of stem cells like bone marrow, peripheral blood and umbilical cord blood are used for the transplantation. Among these umbilical cord blood is currently preferred due to the primitiveness of the derived stem cells and minimal possibilities of graft versus host disease or development of graft induced tumors. One of the problems for these sources is the procurement of sufficient number of donor stem cells. Inadequate number of cells may lead to delayed recovery and decrease survivability of the patient. Thus to overcome the limitation of stem cell number, development of an ex-vivo expansion technology is critically important. The recent emerging technology using nanofiber in combination with growth factors has made a significant improvement to the field of regenerative medicine and a couple of patents have been filed. In this review, we will focus on factors regulating hematopoietic stem cell self-renewal and expansion emphasizing on nanofiber as a supporting matrix.

Original languageEnglish (US)
Pages (from-to)125-134
Number of pages10
JournalRecent Patents on Nanotechnology
Volume4
Issue number2
DOIs
StatePublished - Jun 25 2010

Fingerprint

stem cells
Nanofibers
Stem cells
Intercellular Signaling Peptides and Proteins
expansion
blood
transplantation
Blood
Grafts
procurement
leukemias
patents
bone marrow
medicine
Tumors
emerging
Bone
tumors
recovery
disorders

Keywords

  • Bone marrow
  • Cytokines
  • Expansion
  • Extracellular matrix
  • Hematopoietic
  • Human umbilical cord
  • Nanofiber
  • PES
  • Stem cells
  • ex-vivo

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Engineering(all)

Cite this

A novel technology for hematopoietic stem cell expansion using combination of nanofiber and growth factors. / Lu, Jingwei; Aggarwal, Reeva; Pompili, Vincent J.; Das, Hiranmoy.

In: Recent Patents on Nanotechnology, Vol. 4, No. 2, 25.06.2010, p. 125-134.

Research output: Contribution to journalArticle

Lu, Jingwei ; Aggarwal, Reeva ; Pompili, Vincent J. ; Das, Hiranmoy. / A novel technology for hematopoietic stem cell expansion using combination of nanofiber and growth factors. In: Recent Patents on Nanotechnology. 2010 ; Vol. 4, No. 2. pp. 125-134.
@article{978eba02a6c9435192d60a273a56b1a4,
title = "A novel technology for hematopoietic stem cell expansion using combination of nanofiber and growth factors",
abstract = "Hematopoietic stem cell transplantation has been applied as a standard procedure of treatment for hematological disorders like multiple myeloma and leukemia for several decades. Various sources of stem cells like bone marrow, peripheral blood and umbilical cord blood are used for the transplantation. Among these umbilical cord blood is currently preferred due to the primitiveness of the derived stem cells and minimal possibilities of graft versus host disease or development of graft induced tumors. One of the problems for these sources is the procurement of sufficient number of donor stem cells. Inadequate number of cells may lead to delayed recovery and decrease survivability of the patient. Thus to overcome the limitation of stem cell number, development of an ex-vivo expansion technology is critically important. The recent emerging technology using nanofiber in combination with growth factors has made a significant improvement to the field of regenerative medicine and a couple of patents have been filed. In this review, we will focus on factors regulating hematopoietic stem cell self-renewal and expansion emphasizing on nanofiber as a supporting matrix.",
keywords = "Bone marrow, Cytokines, Expansion, Extracellular matrix, Hematopoietic, Human umbilical cord, Nanofiber, PES, Stem cells, ex-vivo",
author = "Jingwei Lu and Reeva Aggarwal and Pompili, {Vincent J.} and Hiranmoy Das",
year = "2010",
month = "6",
day = "25",
doi = "10.2174/187221010791208777",
language = "English (US)",
volume = "4",
pages = "125--134",
journal = "Recent Patents on Nanotechnology",
issn = "1872-2105",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - A novel technology for hematopoietic stem cell expansion using combination of nanofiber and growth factors

AU - Lu, Jingwei

AU - Aggarwal, Reeva

AU - Pompili, Vincent J.

AU - Das, Hiranmoy

PY - 2010/6/25

Y1 - 2010/6/25

N2 - Hematopoietic stem cell transplantation has been applied as a standard procedure of treatment for hematological disorders like multiple myeloma and leukemia for several decades. Various sources of stem cells like bone marrow, peripheral blood and umbilical cord blood are used for the transplantation. Among these umbilical cord blood is currently preferred due to the primitiveness of the derived stem cells and minimal possibilities of graft versus host disease or development of graft induced tumors. One of the problems for these sources is the procurement of sufficient number of donor stem cells. Inadequate number of cells may lead to delayed recovery and decrease survivability of the patient. Thus to overcome the limitation of stem cell number, development of an ex-vivo expansion technology is critically important. The recent emerging technology using nanofiber in combination with growth factors has made a significant improvement to the field of regenerative medicine and a couple of patents have been filed. In this review, we will focus on factors regulating hematopoietic stem cell self-renewal and expansion emphasizing on nanofiber as a supporting matrix.

AB - Hematopoietic stem cell transplantation has been applied as a standard procedure of treatment for hematological disorders like multiple myeloma and leukemia for several decades. Various sources of stem cells like bone marrow, peripheral blood and umbilical cord blood are used for the transplantation. Among these umbilical cord blood is currently preferred due to the primitiveness of the derived stem cells and minimal possibilities of graft versus host disease or development of graft induced tumors. One of the problems for these sources is the procurement of sufficient number of donor stem cells. Inadequate number of cells may lead to delayed recovery and decrease survivability of the patient. Thus to overcome the limitation of stem cell number, development of an ex-vivo expansion technology is critically important. The recent emerging technology using nanofiber in combination with growth factors has made a significant improvement to the field of regenerative medicine and a couple of patents have been filed. In this review, we will focus on factors regulating hematopoietic stem cell self-renewal and expansion emphasizing on nanofiber as a supporting matrix.

KW - Bone marrow

KW - Cytokines

KW - Expansion

KW - Extracellular matrix

KW - Hematopoietic

KW - Human umbilical cord

KW - Nanofiber

KW - PES

KW - Stem cells

KW - ex-vivo

UR - http://www.scopus.com/inward/record.url?scp=77953781286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953781286&partnerID=8YFLogxK

U2 - 10.2174/187221010791208777

DO - 10.2174/187221010791208777

M3 - Article

C2 - 20420564

AN - SCOPUS:77953781286

VL - 4

SP - 125

EP - 134

JO - Recent Patents on Nanotechnology

JF - Recent Patents on Nanotechnology

SN - 1872-2105

IS - 2

ER -