A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst)

Zenggang Pan, Warren G. Sanger, Julia A. Bridge, William J. Hunter, Gene P. Siegal, Shi Wei

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aneurysmal bone cyst is a rapidly growing and locally aggressive lesion that commonly affects children and young adults. Initially regarded as a reactive process, primary aneurysmal bone cyst is now widely accepted as a neoplasm owing to recent findings of recurrent clonal chromosomal alterations, mostly t(16;17)(q22;p13). However, other infrequent chromosomal rearrangements have also been reported. Giant cell reparative granuloma, previously regarded as a nonneoplastic process and histologically indistinguishable from the solid variant of aneurysmal bone cyst, is frequently seen in the gnathic bones and the short tubular bones of the hands and feet. Here we present such a case of giant cell reparative granuloma (solid aneurysmal bone cyst) in the finger of a 63-year-old white man. Cytogenetic analysis revealed a novel alteration involving a reciprocal translocation between 6q and 13q, with a karyotype of 46,XY,t(6;13)(q15;q34),del(20)(q13.1).

Original languageEnglish (US)
Pages (from-to)952-957
Number of pages6
JournalHuman Pathology
Volume43
Issue number6
DOIs
StatePublished - Jun 1 2012

Fingerprint

Giant Cell Granuloma
Aneurysmal Bone Cysts
Foot Bones
Hand Bones
Cytogenetic Analysis
Karyotype
Fingers
Young Adult
Bone and Bones
Neoplasms

Keywords

  • Aneurysmal bone cyst
  • Giant cell reparative granuloma
  • t(6;13)(q15;q34)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst). / Pan, Zenggang; Sanger, Warren G.; Bridge, Julia A.; Hunter, William J.; Siegal, Gene P.; Wei, Shi.

In: Human Pathology, Vol. 43, No. 6, 01.06.2012, p. 952-957.

Research output: Contribution to journalArticle

Pan, Zenggang ; Sanger, Warren G. ; Bridge, Julia A. ; Hunter, William J. ; Siegal, Gene P. ; Wei, Shi. / A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst). In: Human Pathology. 2012 ; Vol. 43, No. 6. pp. 952-957.
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