A novel role of Shc adaptor proteins in steroid hormone-regulated cancers

Syed Mahfuzul Alam, Mythilypriya Rajendran, Shouqiang Ouyang, Suresh Veeramani, Li Zhang, Ming-Fong Lin

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Tyrosine phosphorylation plays a critical role in growth regulation, and its aberrant regulation can be involved in carcinogenesis. The association of Shc (Src homolog and collagen homolog) adaptor protein family members in tyrosine phosphorylation signaling pathway is well recognized. Shc adaptor proteins transmit activated tyrosine phosphorylation signaling that suggest their plausible role in growth regulation including carcinogenesis and metastasis. In parallel, by sharing a similar mechanism of carcinogenesis, the steroids are involved in the early stage of carcinogenesis as well as the regulation of cancer progression and metastatic processes. Recent evidence indicates a cross-talk between tyrosine phosphorylation signaling and steroid hormone action in epithelial cells, including prostate and breast cancer cells. Therefore, the members of Shc proteins may function as mediators between tyrosine phosphorylation and steroid signaling in steroid-regulated cell proliferation and carcinogenesis. In this communication, we discuss the novel roles of Shc proteins, specifically p52Shc and p66Shc, in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66Shc mediates steroid action via a non-genomic pathway. The p66Shc protein may serve as an effective biomarker for predicting cancer prognosis as well as a useful target for treatment.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalEndocrine-Related Cancer
Volume16
Issue number1
DOIs
StatePublished - Jun 8 2009

Fingerprint

Collagen
Steroids
Tyrosine
Hormones
Carcinogenesis
Phosphorylation
Neoplasms
Proteins
Tumor Biomarkers
Growth
Oxidation-Reduction
Prostatic Neoplasms
Epithelial Cells
Cell Proliferation
Breast Neoplasms
Neoplasm Metastasis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

Cite this

A novel role of Shc adaptor proteins in steroid hormone-regulated cancers. / Alam, Syed Mahfuzul; Rajendran, Mythilypriya; Ouyang, Shouqiang; Veeramani, Suresh; Zhang, Li; Lin, Ming-Fong.

In: Endocrine-Related Cancer, Vol. 16, No. 1, 08.06.2009, p. 1-16.

Research output: Contribution to journalReview article

Alam, SM, Rajendran, M, Ouyang, S, Veeramani, S, Zhang, L & Lin, M-F 2009, 'A novel role of Shc adaptor proteins in steroid hormone-regulated cancers', Endocrine-Related Cancer, vol. 16, no. 1, pp. 1-16. https://doi.org/10.1677/ERC-08-0179
Alam, Syed Mahfuzul ; Rajendran, Mythilypriya ; Ouyang, Shouqiang ; Veeramani, Suresh ; Zhang, Li ; Lin, Ming-Fong. / A novel role of Shc adaptor proteins in steroid hormone-regulated cancers. In: Endocrine-Related Cancer. 2009 ; Vol. 16, No. 1. pp. 1-16.
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