A novel adenovirus isolated from the Egyptian fruit bat in South Africa is closely related to recent isolates from China

Petrus Jansen Van Vuren, Mushal Allam, Michael R Wiley, Arshad Ismail, Nadia Storm, Monica Birkhead, Wanda Markotter, Gustavo Palacios, Janusz T. Paweska

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Abstract

Recently a number of novel adenoviruses have been isolated from diverse bat species and from diverse geographical locations. We describe the isolation of a novel adenovirus (Family Adenoviridae, genus Mastadenovirus) from a pool of liver and spleen tissue of an apparently healthy wild-caught Egyptian fruit bat (Rousettus aegyptiacus) in South Africa. Genetically the virus is most closely related to four mastadenoviruses recently isolated in China, from Miniopterus schreibersi and Rousettus leschenaultii bats, which are highly divergent from previously identified bat adenoviruses. The length of the Rousettus aegyptiacus adenovirus-3085 (RaegAdV-3085) genome, at 29,342 bp is similar to its closest relatives, and contains 27 open reading frames. The RaegAdV-3085 genome has a low G + C content (36.4%) relative to other viruses in the genus (between 43.6 and 63.9%) but similar to its closest relatives. The inverted terminal repeat (ITR) of RaegAdV-3085 is only 40 bp compared to between 61 and 178 bp of its closest relatives. The discovery of RaegAdV-3085 expands the diversity of known adenoviruses in bats and might represent a member of a new mastadenovirus species in bats.

Original languageEnglish (US)
Article number9584
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Mastadenovirus
Rousettus
Adenoviridae
Chiroptera
South Africa
fruits
China
viruses
terminal repeat sequences
genome
Geographical Locations
open reading frames
spleen

ASJC Scopus subject areas

  • General

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A novel adenovirus isolated from the Egyptian fruit bat in South Africa is closely related to recent isolates from China. / Jansen Van Vuren, Petrus; Allam, Mushal; Wiley, Michael R; Ismail, Arshad; Storm, Nadia; Birkhead, Monica; Markotter, Wanda; Palacios, Gustavo; Paweska, Janusz T.

In: Scientific reports, Vol. 8, No. 1, 9584, 01.12.2018.

Research output: Contribution to journalArticle

Jansen Van Vuren, P, Allam, M, Wiley, MR, Ismail, A, Storm, N, Birkhead, M, Markotter, W, Palacios, G & Paweska, JT 2018, 'A novel adenovirus isolated from the Egyptian fruit bat in South Africa is closely related to recent isolates from China', Scientific reports, vol. 8, no. 1, 9584. https://doi.org/10.1038/s41598-018-27836-w
Jansen Van Vuren, Petrus ; Allam, Mushal ; Wiley, Michael R ; Ismail, Arshad ; Storm, Nadia ; Birkhead, Monica ; Markotter, Wanda ; Palacios, Gustavo ; Paweska, Janusz T. / A novel adenovirus isolated from the Egyptian fruit bat in South Africa is closely related to recent isolates from China. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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