A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes

Richard J. Roberts, Marlene Belfort, Timothy Bestor, Ashok S. Bhagwat, Thomas A. Bickle, Jurate Bitinaite, Robert M. Blumenthal, Sergey Kh Degtyarev, David T.F. Dryden, Kevin Dybvig, Keith Firman, Elizaveta S. Gromova, Richard I. Gumport, Stephen E. Halford, Stanley Hattman, Joseph Heitman, David P. Hornby, Arvydas Janulaitis, Albert Jeltsch, Jytte JosephsenAntal Kiss, Todd R. Klaenhammer, Ichizo Kobayashi, Huimin Kong, Detlev H. Krüger, Sanford Lacks, Martin G. Marinus, Michiko Miyahara, Richard D. Morgan, Noreen E. Murray, Valakunja Nagaraja, Andrzej Piekarowicz, Alfred Pingoud, Elisabeth Raleigh, Desirazu N. Rao, Norbert Reich, Vladimir E. Repin, Eric U. Selker, Pang Chui Shaw, Daniel C. Stein, Barry L. Stoddard, Waclaw Szybalski, Thomas A. Trautner, James L. Van Etten, Jorge M.B. Vitor, Geoffrey G. Wilson, Shuang Yong Xu

Research output: Contribution to journalReview article

451 Scopus citations


A nomenclature is described for restriction endonucleases, DNA methyltransferases, homing endonucleases and related genes and gene products. It provides explicit categories for the many different Type II enzymes now identified and provides a system for naming the putative genes found by sequence analysis of microbial genomes.

Original languageEnglish (US)
Pages (from-to)1805-1812
Number of pages8
JournalNucleic acids research
Issue number7
StatePublished - Apr 1 2003


ASJC Scopus subject areas

  • Genetics

Cite this

Roberts, R. J., Belfort, M., Bestor, T., Bhagwat, A. S., Bickle, T. A., Bitinaite, J., Blumenthal, R. M., Degtyarev, S. K., Dryden, D. T. F., Dybvig, K., Firman, K., Gromova, E. S., Gumport, R. I., Halford, S. E., Hattman, S., Heitman, J., Hornby, D. P., Janulaitis, A., Jeltsch, A., ... Xu, S. Y. (2003). A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic acids research, 31(7), 1805-1812. https://doi.org/10.1093/nar/gkg274