A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Protein Expression from Open Reading Frame 2 and an Adjacent Reading Frame during Productive Infection

Yunquan Jiang, Melissa Inman, Yange Zhang, Nuria Alemañ Posadas, Clinton Jones

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The latency-related (LR) gene of bovine herpesvirus 1 (BHV-1) is abundantly expressed during latency. A mutant BHV-1 strain that contains three stop codons at the 5′ terminus of the LR gene (LR mutant) does not reactivate from latency. This study demonstrates that the LR mutant does not express open reading frame 2 or an adjacent reading frame that lacks an initiating ATG (reading frame C). Since the LR mutant and wild-type BHV-1 express similar levels of LR RNA, we conclude that LR protein expression plays an important role in regulating the latency reactivation cycle in cattle.

Original languageEnglish (US)
Pages (from-to)3184-3189
Number of pages6
JournalJournal of virology
Volume78
Issue number6
DOIs
StatePublished - Mar 1 2004

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Bovine Herpesvirus 1
Reading Frames
Bovine herpesvirus 1
Open Reading Frames
open reading frames
protein synthesis
mutation
mutants
Mutation
Infection
infection
Genes
Proteins
genes
Terminator Codon
stop codon
RNA
cattle

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Protein Expression from Open Reading Frame 2 and an Adjacent Reading Frame during Productive Infection. / Jiang, Yunquan; Inman, Melissa; Zhang, Yange; Posadas, Nuria Alemañ; Jones, Clinton.

In: Journal of virology, Vol. 78, No. 6, 01.03.2004, p. 3184-3189.

Research output: Contribution to journalArticle

Jiang, Yunquan ; Inman, Melissa ; Zhang, Yange ; Posadas, Nuria Alemañ ; Jones, Clinton. / A Mutation in the Latency-Related Gene of Bovine Herpesvirus 1 Inhibits Protein Expression from Open Reading Frame 2 and an Adjacent Reading Frame during Productive Infection. In: Journal of virology. 2004 ; Vol. 78, No. 6. pp. 3184-3189.
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