A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics

Amir Nasajpour, Sahar Ansari, Chiara Rinoldi, Afsaneh Shahrokhi Rad, Tara Aghaloo, Su Ryon Shin, Yogendra Kumar Mishra, Rainer Adelung, Wojciech Swieszkowski, Nasim Annabi, Ali Khademhosseini, Alireza Moshaverinia, Ali Tamayol

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth-supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.

Original languageEnglish (US)
Article number1703437
JournalAdvanced Functional Materials
Volume28
Issue number3
DOIs
StatePublished - Jan 17 2018

Fingerprint

Polymeric membranes
membranes
Membranes
Zinc Oxide
regeneration
Tissue regeneration
Zinc oxide
tooth diseases
zinc oxides
Tissue
Composite membranes
Ligaments
ligaments
Bioelectric potentials
Electrospinning
epithelium
tissue engineering
Bioactivity
Tissue engineering
Rats

Keywords

  • electrospinning
  • guided tissue regeneration
  • osteoconductive
  • periodontal regeneration
  • zinc oxide

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrochemistry

Cite this

A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics. / Nasajpour, Amir; Ansari, Sahar; Rinoldi, Chiara; Rad, Afsaneh Shahrokhi; Aghaloo, Tara; Shin, Su Ryon; Mishra, Yogendra Kumar; Adelung, Rainer; Swieszkowski, Wojciech; Annabi, Nasim; Khademhosseini, Ali; Moshaverinia, Alireza; Tamayol, Ali.

In: Advanced Functional Materials, Vol. 28, No. 3, 1703437, 17.01.2018.

Research output: Contribution to journalArticle

Nasajpour, A, Ansari, S, Rinoldi, C, Rad, AS, Aghaloo, T, Shin, SR, Mishra, YK, Adelung, R, Swieszkowski, W, Annabi, N, Khademhosseini, A, Moshaverinia, A & Tamayol, A 2018, 'A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics', Advanced Functional Materials, vol. 28, no. 3, 1703437. https://doi.org/10.1002/adfm.201703437
Nasajpour, Amir ; Ansari, Sahar ; Rinoldi, Chiara ; Rad, Afsaneh Shahrokhi ; Aghaloo, Tara ; Shin, Su Ryon ; Mishra, Yogendra Kumar ; Adelung, Rainer ; Swieszkowski, Wojciech ; Annabi, Nasim ; Khademhosseini, Ali ; Moshaverinia, Alireza ; Tamayol, Ali. / A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics. In: Advanced Functional Materials. 2018 ; Vol. 28, No. 3.
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