A model for predicting primary blast lung injury

Lisa MacFadden, Philemon C. Chan, Kevin H.H. Ho, James H. Stuhmiller

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND: This article presents a model-based method for predicting primary blast injury. On the basis of the normalized work injury mechanism from previous work, this method presents a new model that accounts for the effects of blast orientation and species difference. METHODS: The analysis used test data from a series of extensive experimental studies sponsored by the US Army Medical Research and Materiel Command. In these studies, more than 1200 sheep were exposed to air blast in free-field and confined enclosures, and lung injuries were quantified as the percentage of surface area contused. Blast overpressure data were collected using blast test devices placed at matching locations to represent loadings to the thorax. Adopting the modified Lobdell model with further modifications specifically for blast and scaling, the thorax deformation histories for the left, chest, and right sides of the thorax were calculated for all sheep subjects. Using the calculated thorax velocities, effective normalized work was computed for each test subject representing the irreversible work performed on the lung tissues normalized by lung volume and ambient pressure. RESULTS: Dose-response curves for four categories of injuries (trace, slight, moderate, and severe) were developed by performing log-logistic correlations of the computed normalized work with the injury outcomes, including the effect of multiple shots. A blast lethality correlation was also established. CONCLUSION: Validated by sheep data, the present work revalidates the previous understanding and findings of the blast lung injury mechanism and provides an anthropomorphic model for primary blast injury prediction that can be used for occupational and survivability analysis. LEVEL OF EVIDENCE: Economic and decision analysis, level III.

Original languageEnglish (US)
Pages (from-to)1121-1129
Number of pages9
JournalJournal of Trauma and Acute Care Surgery
Volume73
Issue number5
DOIs
StatePublished - Nov 1 2012

Fingerprint

Blast Injuries
Lung Injury
Thorax
Sheep
Wounds and Injuries
Lung
Decision Support Techniques
Contusions
Biomedical Research
Air
Economics
Pressure
Equipment and Supplies

Keywords

  • Blast overpressure
  • Blast test device
  • Lung injury model
  • Primary blast injury

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

A model for predicting primary blast lung injury. / MacFadden, Lisa; Chan, Philemon C.; Ho, Kevin H.H.; Stuhmiller, James H.

In: Journal of Trauma and Acute Care Surgery, Vol. 73, No. 5, 01.11.2012, p. 1121-1129.

Research output: Contribution to journalArticle

MacFadden, Lisa ; Chan, Philemon C. ; Ho, Kevin H.H. ; Stuhmiller, James H. / A model for predicting primary blast lung injury. In: Journal of Trauma and Acute Care Surgery. 2012 ; Vol. 73, No. 5. pp. 1121-1129.
@article{7d11735d052f4d96b5bc814591ea80df,
title = "A model for predicting primary blast lung injury",
abstract = "BACKGROUND: This article presents a model-based method for predicting primary blast injury. On the basis of the normalized work injury mechanism from previous work, this method presents a new model that accounts for the effects of blast orientation and species difference. METHODS: The analysis used test data from a series of extensive experimental studies sponsored by the US Army Medical Research and Materiel Command. In these studies, more than 1200 sheep were exposed to air blast in free-field and confined enclosures, and lung injuries were quantified as the percentage of surface area contused. Blast overpressure data were collected using blast test devices placed at matching locations to represent loadings to the thorax. Adopting the modified Lobdell model with further modifications specifically for blast and scaling, the thorax deformation histories for the left, chest, and right sides of the thorax were calculated for all sheep subjects. Using the calculated thorax velocities, effective normalized work was computed for each test subject representing the irreversible work performed on the lung tissues normalized by lung volume and ambient pressure. RESULTS: Dose-response curves for four categories of injuries (trace, slight, moderate, and severe) were developed by performing log-logistic correlations of the computed normalized work with the injury outcomes, including the effect of multiple shots. A blast lethality correlation was also established. CONCLUSION: Validated by sheep data, the present work revalidates the previous understanding and findings of the blast lung injury mechanism and provides an anthropomorphic model for primary blast injury prediction that can be used for occupational and survivability analysis. LEVEL OF EVIDENCE: Economic and decision analysis, level III.",
keywords = "Blast overpressure, Blast test device, Lung injury model, Primary blast injury",
author = "Lisa MacFadden and Chan, {Philemon C.} and Ho, {Kevin H.H.} and Stuhmiller, {James H.}",
year = "2012",
month = "11",
day = "1",
doi = "10.1097/TA.0b013e31825c1536",
language = "English (US)",
volume = "73",
pages = "1121--1129",
journal = "Journal of Trauma and Acute Care Surgery",
issn = "2163-0755",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - A model for predicting primary blast lung injury

AU - MacFadden, Lisa

AU - Chan, Philemon C.

AU - Ho, Kevin H.H.

AU - Stuhmiller, James H.

PY - 2012/11/1

Y1 - 2012/11/1

N2 - BACKGROUND: This article presents a model-based method for predicting primary blast injury. On the basis of the normalized work injury mechanism from previous work, this method presents a new model that accounts for the effects of blast orientation and species difference. METHODS: The analysis used test data from a series of extensive experimental studies sponsored by the US Army Medical Research and Materiel Command. In these studies, more than 1200 sheep were exposed to air blast in free-field and confined enclosures, and lung injuries were quantified as the percentage of surface area contused. Blast overpressure data were collected using blast test devices placed at matching locations to represent loadings to the thorax. Adopting the modified Lobdell model with further modifications specifically for blast and scaling, the thorax deformation histories for the left, chest, and right sides of the thorax were calculated for all sheep subjects. Using the calculated thorax velocities, effective normalized work was computed for each test subject representing the irreversible work performed on the lung tissues normalized by lung volume and ambient pressure. RESULTS: Dose-response curves for four categories of injuries (trace, slight, moderate, and severe) were developed by performing log-logistic correlations of the computed normalized work with the injury outcomes, including the effect of multiple shots. A blast lethality correlation was also established. CONCLUSION: Validated by sheep data, the present work revalidates the previous understanding and findings of the blast lung injury mechanism and provides an anthropomorphic model for primary blast injury prediction that can be used for occupational and survivability analysis. LEVEL OF EVIDENCE: Economic and decision analysis, level III.

AB - BACKGROUND: This article presents a model-based method for predicting primary blast injury. On the basis of the normalized work injury mechanism from previous work, this method presents a new model that accounts for the effects of blast orientation and species difference. METHODS: The analysis used test data from a series of extensive experimental studies sponsored by the US Army Medical Research and Materiel Command. In these studies, more than 1200 sheep were exposed to air blast in free-field and confined enclosures, and lung injuries were quantified as the percentage of surface area contused. Blast overpressure data were collected using blast test devices placed at matching locations to represent loadings to the thorax. Adopting the modified Lobdell model with further modifications specifically for blast and scaling, the thorax deformation histories for the left, chest, and right sides of the thorax were calculated for all sheep subjects. Using the calculated thorax velocities, effective normalized work was computed for each test subject representing the irreversible work performed on the lung tissues normalized by lung volume and ambient pressure. RESULTS: Dose-response curves for four categories of injuries (trace, slight, moderate, and severe) were developed by performing log-logistic correlations of the computed normalized work with the injury outcomes, including the effect of multiple shots. A blast lethality correlation was also established. CONCLUSION: Validated by sheep data, the present work revalidates the previous understanding and findings of the blast lung injury mechanism and provides an anthropomorphic model for primary blast injury prediction that can be used for occupational and survivability analysis. LEVEL OF EVIDENCE: Economic and decision analysis, level III.

KW - Blast overpressure

KW - Blast test device

KW - Lung injury model

KW - Primary blast injury

UR - http://www.scopus.com/inward/record.url?scp=84869870357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869870357&partnerID=8YFLogxK

U2 - 10.1097/TA.0b013e31825c1536

DO - 10.1097/TA.0b013e31825c1536

M3 - Article

VL - 73

SP - 1121

EP - 1129

JO - Journal of Trauma and Acute Care Surgery

JF - Journal of Trauma and Acute Care Surgery

SN - 2163-0755

IS - 5

ER -