A mini-review of recent W.O. patents (2004-2005) of novel anti-fungal compounds in the field of anti-infective drug targets.

Weimin Zhang, Donald F Becker, Q. Cheng

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Anti-infective agents are used to treat disorders caused by bacteria, viruses, protozoa, worms, and fungi (including yeast). They are substances used on humans, animals and plants that destroy harmful microorganisms or inhibit their activity. In this mini-review, we are focusing on novel development of anti-fungal agents that have been published during the past two years. Fungi are eukaryotic microorganisms comprising over 100,000 species. Nearly 40% of all deaths from hospital-acquired infections were caused by fungi over the past 20 years. An effective anti-fungal agent is toxic to the pathogenic fungi, but not to the host. Treatment of fungi diseases, however, is often limited because anti-fungal agents are often toxic to the mammalian or plant host. In this review, 11 patents were chronologically and unbiasedly selected from 454 that fit the criteria out of a 4,716,037 patents search. These patents highlight the novel approaches that have been used to tackle difficult fungi. The strategies include targeting key fungal structures and metabolic pathways, developing manufacturing processes of anti-fungal reagents, unique membrane interfering fungicides, and plant and insect defensins.

Original languageEnglish (US)
Pages (from-to)225-230
Number of pages6
JournalRecent patents on anti-infective drug discovery
Volume1
Issue number2
DOIs
StatePublished - Jun 2006

Fingerprint

Patents
Fungi
Pharmaceutical Preparations
Poisons
Fungal Structures
Defensins
Mycoses
Cross Infection
Anti-Infective Agents
Metabolic Networks and Pathways
Insects
Yeasts
Viruses
Bacteria
Membranes

ASJC Scopus subject areas

  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

A mini-review of recent W.O. patents (2004-2005) of novel anti-fungal compounds in the field of anti-infective drug targets. / Zhang, Weimin; Becker, Donald F; Cheng, Q.

In: Recent patents on anti-infective drug discovery, Vol. 1, No. 2, 06.2006, p. 225-230.

Research output: Contribution to journalReview article

@article{4575a12563de4591be6693ed4a4d684f,
title = "A mini-review of recent W.O. patents (2004-2005) of novel anti-fungal compounds in the field of anti-infective drug targets.",
abstract = "Anti-infective agents are used to treat disorders caused by bacteria, viruses, protozoa, worms, and fungi (including yeast). They are substances used on humans, animals and plants that destroy harmful microorganisms or inhibit their activity. In this mini-review, we are focusing on novel development of anti-fungal agents that have been published during the past two years. Fungi are eukaryotic microorganisms comprising over 100,000 species. Nearly 40{\%} of all deaths from hospital-acquired infections were caused by fungi over the past 20 years. An effective anti-fungal agent is toxic to the pathogenic fungi, but not to the host. Treatment of fungi diseases, however, is often limited because anti-fungal agents are often toxic to the mammalian or plant host. In this review, 11 patents were chronologically and unbiasedly selected from 454 that fit the criteria out of a 4,716,037 patents search. These patents highlight the novel approaches that have been used to tackle difficult fungi. The strategies include targeting key fungal structures and metabolic pathways, developing manufacturing processes of anti-fungal reagents, unique membrane interfering fungicides, and plant and insect defensins.",
author = "Weimin Zhang and Becker, {Donald F} and Q. Cheng",
year = "2006",
month = "6",
doi = "10.2174/157489106777452584",
language = "English (US)",
volume = "1",
pages = "225--230",
journal = "Recent Patents on Anti-Infective Drug Discovery",
issn = "1574-891X",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - A mini-review of recent W.O. patents (2004-2005) of novel anti-fungal compounds in the field of anti-infective drug targets.

AU - Zhang, Weimin

AU - Becker, Donald F

AU - Cheng, Q.

PY - 2006/6

Y1 - 2006/6

N2 - Anti-infective agents are used to treat disorders caused by bacteria, viruses, protozoa, worms, and fungi (including yeast). They are substances used on humans, animals and plants that destroy harmful microorganisms or inhibit their activity. In this mini-review, we are focusing on novel development of anti-fungal agents that have been published during the past two years. Fungi are eukaryotic microorganisms comprising over 100,000 species. Nearly 40% of all deaths from hospital-acquired infections were caused by fungi over the past 20 years. An effective anti-fungal agent is toxic to the pathogenic fungi, but not to the host. Treatment of fungi diseases, however, is often limited because anti-fungal agents are often toxic to the mammalian or plant host. In this review, 11 patents were chronologically and unbiasedly selected from 454 that fit the criteria out of a 4,716,037 patents search. These patents highlight the novel approaches that have been used to tackle difficult fungi. The strategies include targeting key fungal structures and metabolic pathways, developing manufacturing processes of anti-fungal reagents, unique membrane interfering fungicides, and plant and insect defensins.

AB - Anti-infective agents are used to treat disorders caused by bacteria, viruses, protozoa, worms, and fungi (including yeast). They are substances used on humans, animals and plants that destroy harmful microorganisms or inhibit their activity. In this mini-review, we are focusing on novel development of anti-fungal agents that have been published during the past two years. Fungi are eukaryotic microorganisms comprising over 100,000 species. Nearly 40% of all deaths from hospital-acquired infections were caused by fungi over the past 20 years. An effective anti-fungal agent is toxic to the pathogenic fungi, but not to the host. Treatment of fungi diseases, however, is often limited because anti-fungal agents are often toxic to the mammalian or plant host. In this review, 11 patents were chronologically and unbiasedly selected from 454 that fit the criteria out of a 4,716,037 patents search. These patents highlight the novel approaches that have been used to tackle difficult fungi. The strategies include targeting key fungal structures and metabolic pathways, developing manufacturing processes of anti-fungal reagents, unique membrane interfering fungicides, and plant and insect defensins.

UR - http://www.scopus.com/inward/record.url?scp=39749145843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39749145843&partnerID=8YFLogxK

U2 - 10.2174/157489106777452584

DO - 10.2174/157489106777452584

M3 - Review article

C2 - 18221147

AN - SCOPUS:39749145843

VL - 1

SP - 225

EP - 230

JO - Recent Patents on Anti-Infective Drug Discovery

JF - Recent Patents on Anti-Infective Drug Discovery

SN - 1574-891X

IS - 2

ER -