A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss)

M. R. Baerwald, Jessica L Petersen, R. P. Hedrick, G. J. Schisler, B. May

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Whirling disease, caused by the pathogen Myxobolus cerebralis, leads to skeletal deformation, neurological impairment and under certain conditions, mortality of juvenile salmonid fishes. The disease has impacted the propagation and survival of many salmonid species over six continents, with particularly negative consequences for rainbow trout. To assess the genetic basis of whirling disease resistance in rainbow trout, genome-wide mapping was initiated using a large outbred F2 rainbow trout family (n=480) and results were confirmed in three additional outbred F2 families (n=96 per family). A single quantitative trait locus (QTL) region on chromosome Omy9 was identified in the large mapping family and confirmed in all additional families. This region explains 50-86% of the phenotypic variance across families. Therefore, these data establish that a single QTL region is capable of explaining a large percentage of the phenotypic variance contributing to whirling disease resistance. This is the first genetic region discovered that contributes directly to the whirling disease phenotype and the finding moves the field closer to a mechanistic understanding of resistance to this important disease of salmonid fish.

Original languageEnglish (US)
Pages (from-to)920-926
Number of pages7
JournalHeredity
Volume106
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Disease Resistance
Oncorhynchus mykiss
Quantitative Trait Loci
Myxobolus
Fish Diseases
Chromosome Mapping
Fishes
Chromosomes
Phenotype
Mortality

Keywords

  • Myxobolus cerebralis
  • QTL
  • Whirling disease
  • disease mapping
  • myxozoan pathogen
  • rainbow trout

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss). / Baerwald, M. R.; Petersen, Jessica L; Hedrick, R. P.; Schisler, G. J.; May, B.

In: Heredity, Vol. 106, No. 6, 01.06.2011, p. 920-926.

Research output: Contribution to journalArticle

Baerwald, M. R. ; Petersen, Jessica L ; Hedrick, R. P. ; Schisler, G. J. ; May, B. / A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss). In: Heredity. 2011 ; Vol. 106, No. 6. pp. 920-926.
@article{2ec9b09a621f46ef94b0443cd149e6b5,
title = "A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss)",
abstract = "Whirling disease, caused by the pathogen Myxobolus cerebralis, leads to skeletal deformation, neurological impairment and under certain conditions, mortality of juvenile salmonid fishes. The disease has impacted the propagation and survival of many salmonid species over six continents, with particularly negative consequences for rainbow trout. To assess the genetic basis of whirling disease resistance in rainbow trout, genome-wide mapping was initiated using a large outbred F2 rainbow trout family (n=480) and results were confirmed in three additional outbred F2 families (n=96 per family). A single quantitative trait locus (QTL) region on chromosome Omy9 was identified in the large mapping family and confirmed in all additional families. This region explains 50-86{\%} of the phenotypic variance across families. Therefore, these data establish that a single QTL region is capable of explaining a large percentage of the phenotypic variance contributing to whirling disease resistance. This is the first genetic region discovered that contributes directly to the whirling disease phenotype and the finding moves the field closer to a mechanistic understanding of resistance to this important disease of salmonid fish.",
keywords = "Myxobolus cerebralis, QTL, Whirling disease, disease mapping, myxozoan pathogen, rainbow trout",
author = "Baerwald, {M. R.} and Petersen, {Jessica L} and Hedrick, {R. P.} and Schisler, {G. J.} and B. May",
year = "2011",
month = "6",
day = "1",
doi = "10.1038/hdy.2010.137",
language = "English (US)",
volume = "106",
pages = "920--926",
journal = "Heredity",
issn = "0018-067X",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss)

AU - Baerwald, M. R.

AU - Petersen, Jessica L

AU - Hedrick, R. P.

AU - Schisler, G. J.

AU - May, B.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Whirling disease, caused by the pathogen Myxobolus cerebralis, leads to skeletal deformation, neurological impairment and under certain conditions, mortality of juvenile salmonid fishes. The disease has impacted the propagation and survival of many salmonid species over six continents, with particularly negative consequences for rainbow trout. To assess the genetic basis of whirling disease resistance in rainbow trout, genome-wide mapping was initiated using a large outbred F2 rainbow trout family (n=480) and results were confirmed in three additional outbred F2 families (n=96 per family). A single quantitative trait locus (QTL) region on chromosome Omy9 was identified in the large mapping family and confirmed in all additional families. This region explains 50-86% of the phenotypic variance across families. Therefore, these data establish that a single QTL region is capable of explaining a large percentage of the phenotypic variance contributing to whirling disease resistance. This is the first genetic region discovered that contributes directly to the whirling disease phenotype and the finding moves the field closer to a mechanistic understanding of resistance to this important disease of salmonid fish.

AB - Whirling disease, caused by the pathogen Myxobolus cerebralis, leads to skeletal deformation, neurological impairment and under certain conditions, mortality of juvenile salmonid fishes. The disease has impacted the propagation and survival of many salmonid species over six continents, with particularly negative consequences for rainbow trout. To assess the genetic basis of whirling disease resistance in rainbow trout, genome-wide mapping was initiated using a large outbred F2 rainbow trout family (n=480) and results were confirmed in three additional outbred F2 families (n=96 per family). A single quantitative trait locus (QTL) region on chromosome Omy9 was identified in the large mapping family and confirmed in all additional families. This region explains 50-86% of the phenotypic variance across families. Therefore, these data establish that a single QTL region is capable of explaining a large percentage of the phenotypic variance contributing to whirling disease resistance. This is the first genetic region discovered that contributes directly to the whirling disease phenotype and the finding moves the field closer to a mechanistic understanding of resistance to this important disease of salmonid fish.

KW - Myxobolus cerebralis

KW - QTL

KW - Whirling disease

KW - disease mapping

KW - myxozoan pathogen

KW - rainbow trout

UR - http://www.scopus.com/inward/record.url?scp=79956348641&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79956348641&partnerID=8YFLogxK

U2 - 10.1038/hdy.2010.137

DO - 10.1038/hdy.2010.137

M3 - Article

VL - 106

SP - 920

EP - 926

JO - Heredity

JF - Heredity

SN - 0018-067X

IS - 6

ER -