A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy

S. L. Rauch, N. Makris, G. Rees Cosgrove, H. Kim, E. H. Cassem, B. H. Price, L. Baer, Cary R Savage, V. S. Caviness, M. A. Jenike, D. N. Kennedy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The purpose of this study was to test the hypothesis that orbitofrontal cortical volume would be reduced following anterior cingulotomy for obsessive-compulsive disorder (OCD). Whole brain cortical parcellation was performed on magnetic resonance imaging (MRI) data from nine patients, before and 9 (±6) months following anterior cingulotomy. No significant volumetric reductions were found in the orbitofrontal cortex. Exploratory findings of reduced volume in ventral temporo-fusiform and posterior cingulate regions were consistent with chance differences, in the face of multiple comparisons. Therefore, though the circumscribed lesions of anterior cingulotomy have recently been associated with corresponding volumetric reductions in the caudate nucleus, no comparable volumetric reductions are evident in cortical territories. Taken together, these results are most consistent with a model of cingulo-striatal perturbation as a putative mechanism for the efficacy of this procedure. While limitations in sensitivity may have also contributed to these negative findings, the methods employed have previously proven sufficient to detect cortical volumetric abnormalities in OCD. The current results may reflect a relatively diffuse pattern of corticocortical connections involving the neurons at the site of cingulotomy lesions. Future functional neuroimaging studies are warranted to assess possible cortical or subcortical metabolic changes associated with anterior cingulotomy, as well as predictors of treatment response.

Original languageEnglish (US)
Pages (from-to)214-222
Number of pages9
JournalCNS Spectrums
Volume6
Issue number3
DOIs
StatePublished - Jan 1 2001

Fingerprint

Obsessive-Compulsive Disorder
Magnetic Resonance Imaging
Corpus Striatum
Functional Neuroimaging
Caudate Nucleus
Gyrus Cinguli
Prefrontal Cortex
Neurons
Brain
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Rauch, S. L., Makris, N., Rees Cosgrove, G., Kim, H., Cassem, E. H., Price, B. H., ... Kennedy, D. N. (2001). A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy. CNS Spectrums, 6(3), 214-222. https://doi.org/10.1017/S1092852900008592

A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy. / Rauch, S. L.; Makris, N.; Rees Cosgrove, G.; Kim, H.; Cassem, E. H.; Price, B. H.; Baer, L.; Savage, Cary R; Caviness, V. S.; Jenike, M. A.; Kennedy, D. N.

In: CNS Spectrums, Vol. 6, No. 3, 01.01.2001, p. 214-222.

Research output: Contribution to journalArticle

Rauch, SL, Makris, N, Rees Cosgrove, G, Kim, H, Cassem, EH, Price, BH, Baer, L, Savage, CR, Caviness, VS, Jenike, MA & Kennedy, DN 2001, 'A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy', CNS Spectrums, vol. 6, no. 3, pp. 214-222. https://doi.org/10.1017/S1092852900008592
Rauch, S. L. ; Makris, N. ; Rees Cosgrove, G. ; Kim, H. ; Cassem, E. H. ; Price, B. H. ; Baer, L. ; Savage, Cary R ; Caviness, V. S. ; Jenike, M. A. ; Kennedy, D. N. / A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy. In: CNS Spectrums. 2001 ; Vol. 6, No. 3. pp. 214-222.
@article{270e3ad163da44a29b3e3cbccee9a75a,
title = "A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy",
abstract = "The purpose of this study was to test the hypothesis that orbitofrontal cortical volume would be reduced following anterior cingulotomy for obsessive-compulsive disorder (OCD). Whole brain cortical parcellation was performed on magnetic resonance imaging (MRI) data from nine patients, before and 9 (±6) months following anterior cingulotomy. No significant volumetric reductions were found in the orbitofrontal cortex. Exploratory findings of reduced volume in ventral temporo-fusiform and posterior cingulate regions were consistent with chance differences, in the face of multiple comparisons. Therefore, though the circumscribed lesions of anterior cingulotomy have recently been associated with corresponding volumetric reductions in the caudate nucleus, no comparable volumetric reductions are evident in cortical territories. Taken together, these results are most consistent with a model of cingulo-striatal perturbation as a putative mechanism for the efficacy of this procedure. While limitations in sensitivity may have also contributed to these negative findings, the methods employed have previously proven sufficient to detect cortical volumetric abnormalities in OCD. The current results may reflect a relatively diffuse pattern of corticocortical connections involving the neurons at the site of cingulotomy lesions. Future functional neuroimaging studies are warranted to assess possible cortical or subcortical metabolic changes associated with anterior cingulotomy, as well as predictors of treatment response.",
author = "Rauch, {S. L.} and N. Makris and {Rees Cosgrove}, G. and H. Kim and Cassem, {E. H.} and Price, {B. H.} and L. Baer and Savage, {Cary R} and Caviness, {V. S.} and Jenike, {M. A.} and Kennedy, {D. N.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1017/S1092852900008592",
language = "English (US)",
volume = "6",
pages = "214--222",
journal = "CNS Spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "3",

}

TY - JOUR

T1 - A magnetic resonance imaging study of regional cortical volumes following stereotactic anterior cingulotomy

AU - Rauch, S. L.

AU - Makris, N.

AU - Rees Cosgrove, G.

AU - Kim, H.

AU - Cassem, E. H.

AU - Price, B. H.

AU - Baer, L.

AU - Savage, Cary R

AU - Caviness, V. S.

AU - Jenike, M. A.

AU - Kennedy, D. N.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - The purpose of this study was to test the hypothesis that orbitofrontal cortical volume would be reduced following anterior cingulotomy for obsessive-compulsive disorder (OCD). Whole brain cortical parcellation was performed on magnetic resonance imaging (MRI) data from nine patients, before and 9 (±6) months following anterior cingulotomy. No significant volumetric reductions were found in the orbitofrontal cortex. Exploratory findings of reduced volume in ventral temporo-fusiform and posterior cingulate regions were consistent with chance differences, in the face of multiple comparisons. Therefore, though the circumscribed lesions of anterior cingulotomy have recently been associated with corresponding volumetric reductions in the caudate nucleus, no comparable volumetric reductions are evident in cortical territories. Taken together, these results are most consistent with a model of cingulo-striatal perturbation as a putative mechanism for the efficacy of this procedure. While limitations in sensitivity may have also contributed to these negative findings, the methods employed have previously proven sufficient to detect cortical volumetric abnormalities in OCD. The current results may reflect a relatively diffuse pattern of corticocortical connections involving the neurons at the site of cingulotomy lesions. Future functional neuroimaging studies are warranted to assess possible cortical or subcortical metabolic changes associated with anterior cingulotomy, as well as predictors of treatment response.

AB - The purpose of this study was to test the hypothesis that orbitofrontal cortical volume would be reduced following anterior cingulotomy for obsessive-compulsive disorder (OCD). Whole brain cortical parcellation was performed on magnetic resonance imaging (MRI) data from nine patients, before and 9 (±6) months following anterior cingulotomy. No significant volumetric reductions were found in the orbitofrontal cortex. Exploratory findings of reduced volume in ventral temporo-fusiform and posterior cingulate regions were consistent with chance differences, in the face of multiple comparisons. Therefore, though the circumscribed lesions of anterior cingulotomy have recently been associated with corresponding volumetric reductions in the caudate nucleus, no comparable volumetric reductions are evident in cortical territories. Taken together, these results are most consistent with a model of cingulo-striatal perturbation as a putative mechanism for the efficacy of this procedure. While limitations in sensitivity may have also contributed to these negative findings, the methods employed have previously proven sufficient to detect cortical volumetric abnormalities in OCD. The current results may reflect a relatively diffuse pattern of corticocortical connections involving the neurons at the site of cingulotomy lesions. Future functional neuroimaging studies are warranted to assess possible cortical or subcortical metabolic changes associated with anterior cingulotomy, as well as predictors of treatment response.

UR - http://www.scopus.com/inward/record.url?scp=0034969770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034969770&partnerID=8YFLogxK

U2 - 10.1017/S1092852900008592

DO - 10.1017/S1092852900008592

M3 - Article

VL - 6

SP - 214

EP - 222

JO - CNS Spectrums

JF - CNS Spectrums

SN - 1092-8529

IS - 3

ER -