A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment

Steven A. Parkison, Jay D. Carlson, Tammy R. Chaudoin, Traci A. Hoke, A. Katrin Schenk, Evan H. Goulding, Lance C Perez, Stephen J Bonasera

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

Inexpensive, high-throughput, low maintenance systems for precise temporal and spatial measurement of mouse home cage behavior (including movement, feeding, and drinking) are required to evaluate products from large scale pharmaceutical design and genetic lesion programs. These measurements are also required to interpret results from more focused behavioral assays. We describe the design and validation of a highly-scalable, reliable mouse home cage behavioral monitoring system modeled on a previously described, one-of-a-kind system [1]. Mouse position was determined by solving static equilibrium equations describing the force and torques acting on the system strain gauges; feeding events were detected by a photobeam across the food hopper, and drinking events were detected by a capacitive lick sensor. Validation studies show excellent agreement between mouse position and drinking events measured by the system compared with video-based observation a gold standard in neuroscience.

Original languageEnglish (US)
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages2392-2395
Number of pages4
DOIs
StatePublished - Dec 14 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

Conference34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
CountryUnited States
CitySan Diego, CA
Period8/28/129/1/12

Fingerprint

Rodentia
Throughput
Drinking
Costs and Cost Analysis
Capacitive sensors
Hoppers
Strain gages
Drug products
Costs
Assays
Torque
Monitoring
Validation Studies
Neurosciences
Maintenance
Observation
Food
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Parkison, S. A., Carlson, J. D., Chaudoin, T. R., Hoke, T. A., Schenk, A. K., Goulding, E. H., ... Bonasera, S. J. (2012). A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012 (pp. 2392-2395). [6346445] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6346445

A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. / Parkison, Steven A.; Carlson, Jay D.; Chaudoin, Tammy R.; Hoke, Traci A.; Schenk, A. Katrin; Goulding, Evan H.; Perez, Lance C; Bonasera, Stephen J.

2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. p. 2392-2395 6346445 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Parkison, SA, Carlson, JD, Chaudoin, TR, Hoke, TA, Schenk, AK, Goulding, EH, Perez, LC & Bonasera, SJ 2012, A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. in 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012., 6346445, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 2392-2395, 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012, San Diego, CA, United States, 8/28/12. https://doi.org/10.1109/EMBC.2012.6346445
Parkison SA, Carlson JD, Chaudoin TR, Hoke TA, Schenk AK, Goulding EH et al. A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. p. 2392-2395. 6346445. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2012.6346445
Parkison, Steven A. ; Carlson, Jay D. ; Chaudoin, Tammy R. ; Hoke, Traci A. ; Schenk, A. Katrin ; Goulding, Evan H. ; Perez, Lance C ; Bonasera, Stephen J. / A low-cost, reliable, high-throughput system for rodent behavioral phenotyping in a home cage environment. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012. 2012. pp. 2392-2395 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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