A Long-Term Study of Reversible and Progressive Urinary Bladder Cancer Lesions in Rats Fed N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide1

Jerome B. Jacobs, Masayuki Arai, Samuel M. Cohen, Gilbert H. Friedell

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76 Citations (Scopus)

Abstract

Hyperplasia and, ultimately, neoplasia of bladder epithelium were produced by feeding 0.2% N-[4-(5-nitro-2-furyl)-2-thiazolyljformamide (FANFT) to weanling male Fischer rats. Hyperplasia induced by FANFT feeding for 2, 4, or 6 weeks, followed by feeding control diet until the end of the 84-week experiment, was reversible, and at the end of the experiment bladder epithelium in these animals was normal by light and scanning electron microscopy. Hyperplasia produced by 8 or more weeks of FANFT feeding was irreversible and by 84 weeks had resulted in bladder tumors in all animals fed FANFT for 12 or more weeks and in 4 of 5 and 6 of 7 animals fed FANFT for 8 and 10 weeks, respectively. The epithelial changes after 6 and 8 weeks of FANFT were similar by light microscopy but different by scanning electron microscopy. Pleomorphic microvilli seen with scanning electron microscopy are the hallmark of irreversible, and possibly progressive, epithelial proliferative change.

Original languageEnglish (US)
Pages (from-to)2817-2821
Number of pages5
JournalCancer Research
Volume37
StatePublished - Aug 1977

Fingerprint

FANFT
Urinary Bladder Neoplasms
Electron Scanning Microscopy
Hyperplasia
Urinary Bladder
Epithelium
Light
Inbred F344 Rats
Microvilli
Microscopy
Diet

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A Long-Term Study of Reversible and Progressive Urinary Bladder Cancer Lesions in Rats Fed N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide1. / Jacobs, Jerome B.; Arai, Masayuki; Cohen, Samuel M.; Friedell, Gilbert H.

In: Cancer Research, Vol. 37, 08.1977, p. 2817-2821.

Research output: Contribution to journalArticle

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