A jejunoileal bypass rat model for rapid study of the effects of vitamin malabsorption.

H. Baker, J. A. Vanderhoof, D. J. Tuma, O. Frank, E. R. Baker, M. F. Sorrell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Jejunoileal bypass operation was originally done to promote weight loss for treatment of morbid obesity. We used such a model to determine if dietary vitamin absorption is compromised by such an operation. Six rats were subjected to a jejunoileal bypass, 6 control rats were pair-fed to bypassed rats; and 6 were fed ad libitum. Vitamin content of folic, B6, riboflavin, nicotinate, pantothenate, thiamin, biotin, B12, vitamins A, E, and carotene in blood and liver was determined after 8 postoperative weeks. Aside from riboflavin, blood vitamin levels were significantly depressed in bypassed rats. The deepest depression was seen for B12, carotene and vitamin E. Liver vitamin stores of folate, riboflavin, thiamin, B12, clearly were significantly depressed in the bypassed animals compared to the pair-fed and ad libitum-fed controls. This model can serve for rapidly studying micronutrient depletion due to malabsorption without dietary manipulation or antibiotics for gut sterilization.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalInternational Journal for Vitamin and Nutrition Research
Volume62
Issue number1
StatePublished - Jan 1 1992

Fingerprint

Jejunoileal Bypass
malabsorption
Vitamins
Riboflavin
vitamins
riboflavin
animal models
Thiamine
rats
Carotenoids
carotenes
thiamin
Vitamin E
vitamin content
liver
Morbid Obesity
Micronutrients
Niacin
Liver
blood

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

A jejunoileal bypass rat model for rapid study of the effects of vitamin malabsorption. / Baker, H.; Vanderhoof, J. A.; Tuma, D. J.; Frank, O.; Baker, E. R.; Sorrell, M. F.

In: International Journal for Vitamin and Nutrition Research, Vol. 62, No. 1, 01.01.1992, p. 43-46.

Research output: Contribution to journalArticle

Baker, H. ; Vanderhoof, J. A. ; Tuma, D. J. ; Frank, O. ; Baker, E. R. ; Sorrell, M. F. / A jejunoileal bypass rat model for rapid study of the effects of vitamin malabsorption. In: International Journal for Vitamin and Nutrition Research. 1992 ; Vol. 62, No. 1. pp. 43-46.
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