A Hg(ii)-mediated "signal-on" electrochemical glutathione sensor

Hamid R. Lotfi Zadeh Zhad, Rebecca Y. Lai

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(ii), displacing it from the thymine-Hg(ii)-thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva. This journal is

Original languageEnglish (US)
Pages (from-to)8385-8387
Number of pages3
JournalChemical Communications
Volume50
Issue number61
DOIs
StatePublished - Aug 7 2014

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Thymine
Glutathione
DNA
Immobilized Nucleic Acids
Electrochemical sensors
DNA Probes
Sensors
Mercury
Fabrication

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

A Hg(ii)-mediated "signal-on" electrochemical glutathione sensor. / Lotfi Zadeh Zhad, Hamid R.; Lai, Rebecca Y.

In: Chemical Communications, Vol. 50, No. 61, 07.08.2014, p. 8385-8387.

Research output: Contribution to journalArticle

Lotfi Zadeh Zhad, Hamid R. ; Lai, Rebecca Y. / A Hg(ii)-mediated "signal-on" electrochemical glutathione sensor. In: Chemical Communications. 2014 ; Vol. 50, No. 61. pp. 8385-8387.
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