A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses

Yiming Cheng, Dario Ghersi, Claudia Calcagno, Liisa K. Selin, Roberto Puzone, Franco Celada

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

In an agent-based computer model, we simulate the formation and recall of anti-virus immunological memory. Specifically we try to predict what will happen, both to the response and to memory, when the second infecting virus is partly different from the first one, and when the cross-reactivity of the two branches of the immune system (IS), humoral and cellular, is asymmetrical, or "split". The simulations explore systematically epitope distances, and measure all changes in affinity, cellularity and efficiency in clearing the infection. Besides obvious cooperations, they reveal powerful competitions between the branches, and more intriguing, between cross-reacting and new responses when the latter suffer the competition by preformed cell-rich but inefficient clones, as memory, usually an asset, becomes a liability.

Original languageEnglish (US)
Pages (from-to)833-845
Number of pages13
JournalVaccine
Volume27
Issue number6
DOIs
StatePublished - Feb 5 2009

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Keywords

  • Agent-based computer model
  • Cellular/humoral response
  • Viral cross-reactivity

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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