A detailed phylogenetic analysis of FIV in the United States

Research output: Contribution to journalArticle

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Abstract

Background: Feline immunodeficiency virus (FIV) is a lentivirus associated with AIDS-like illnesses in cats and has been used as a model for the study of human immunodeficiency virus (HIV). A feature of HIV and FIV infection is the continually increasing divergence among viral isolates between different individuals, as well as within the same individuals. Methodology/Principal Findings: The goal of this study was to determine the phylogenetic patterns of viral isolates obtained within the United States (U.S.) by focusing on the variable, V3-V4, region of the FIV envelope gene. Conclusions/Significance: Data indicate that FIV, from within the U.S., localize to four viral clades, A, B, C, and F. Also shown is the geographic isolation of strains where clade A and clade B are found predominately on the west coast; however, clade B is also found throughout the U.S. and represents the predominant clade. This study presents a complete and conclusive analysis of FIV isolates from within the U.S. and may be used as the essential basis for the development of an effective multiclade vaccine.

Original languageEnglish (US)
Article numbere12004
JournalPloS one
Volume5
Issue number8
DOIs
StatePublished - Oct 15 2010

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Feline Immunodeficiency Virus
Feline immunodeficiency virus
Viruses
phylogeny
Human immunodeficiency virus
HIV
Lentivirus
Virus Diseases
Acquired Immunodeficiency Syndrome
Cats
Vaccines
cats
vaccines
coasts
Coastal zones
Genes
infection
genes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

A detailed phylogenetic analysis of FIV in the United States. / Weaver, Eric A.

In: PloS one, Vol. 5, No. 8, e12004, 15.10.2010.

Research output: Contribution to journalArticle

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