A decrease in thymus-mediated immune responses as a result of treatment of neonatal rats with glutamate

Charles A. Blake, David A. Crouse, M. Olubunmi Dada, Jorge F. Rodriguez-Sierra, John G Sharp

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated whether administration of monosodium l-glutamate (MSG) to neonatal rats would disrupt immune responses in intact and orchidectomized adult male rats. Neonatal male rats were treated with saline or MSG which causes severe endocrine abnormalities. Half of each group of animals were orchidectomized as adults and killed one week later along with intact rats. MSG treatment resulted in suppressed serum LH levels in intact rats. Thymus weight and spleen cellularity in intact animals were not affected by MSG treatment, but thymus weight increased within one week after orchidectomy in both saline- and MSG-treated groups. In intact rats, lymphocyte stimulation by the T cell specific mitogens (concanavalin A or phytohemagglutinin) or the B cell specific mitogen (lipopolysaccharide) was unaffected by prior treatment with MSG. However, MSG treatment blocked the decrease attributable to orchidectomy in concanavalin A and phytohemagglutinin stimulation of lymphocyte blastogenesis. The results suggest that administration of MSG to neonatal male rats can alter some immune responses in the adult animal.

Original languageEnglish (US)
Pages (from-to)789-795
Number of pages7
JournalLife Sciences
Volume35
Issue number7
DOIs
StatePublished - Aug 13 1984

Fingerprint

Thymus
Sodium Glutamate
Thymus Gland
Rats
Glutamic Acid
Lymphocyte Activation
Animals
Orchiectomy
Lymphocytes
Phytohemagglutinins
Concanavalin A
Mitogens
Weights and Measures
T-cells
Lipopolysaccharides
B-Lymphocytes
Spleen
Cells
T-Lymphocytes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A decrease in thymus-mediated immune responses as a result of treatment of neonatal rats with glutamate. / Blake, Charles A.; Crouse, David A.; Olubunmi Dada, M.; Rodriguez-Sierra, Jorge F.; Sharp, John G.

In: Life Sciences, Vol. 35, No. 7, 13.08.1984, p. 789-795.

Research output: Contribution to journalArticle

Blake, Charles A. ; Crouse, David A. ; Olubunmi Dada, M. ; Rodriguez-Sierra, Jorge F. ; Sharp, John G. / A decrease in thymus-mediated immune responses as a result of treatment of neonatal rats with glutamate. In: Life Sciences. 1984 ; Vol. 35, No. 7. pp. 789-795.
@article{f4e5f5a3d48a40f4955cb9f46da7edc4,
title = "A decrease in thymus-mediated immune responses as a result of treatment of neonatal rats with glutamate",
abstract = "We investigated whether administration of monosodium l-glutamate (MSG) to neonatal rats would disrupt immune responses in intact and orchidectomized adult male rats. Neonatal male rats were treated with saline or MSG which causes severe endocrine abnormalities. Half of each group of animals were orchidectomized as adults and killed one week later along with intact rats. MSG treatment resulted in suppressed serum LH levels in intact rats. Thymus weight and spleen cellularity in intact animals were not affected by MSG treatment, but thymus weight increased within one week after orchidectomy in both saline- and MSG-treated groups. In intact rats, lymphocyte stimulation by the T cell specific mitogens (concanavalin A or phytohemagglutinin) or the B cell specific mitogen (lipopolysaccharide) was unaffected by prior treatment with MSG. However, MSG treatment blocked the decrease attributable to orchidectomy in concanavalin A and phytohemagglutinin stimulation of lymphocyte blastogenesis. The results suggest that administration of MSG to neonatal male rats can alter some immune responses in the adult animal.",
author = "Blake, {Charles A.} and Crouse, {David A.} and {Olubunmi Dada}, M. and Rodriguez-Sierra, {Jorge F.} and Sharp, {John G}",
year = "1984",
month = "8",
day = "13",
doi = "10.1016/0024-3205(84)90349-7",
language = "English (US)",
volume = "35",
pages = "789--795",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - A decrease in thymus-mediated immune responses as a result of treatment of neonatal rats with glutamate

AU - Blake, Charles A.

AU - Crouse, David A.

AU - Olubunmi Dada, M.

AU - Rodriguez-Sierra, Jorge F.

AU - Sharp, John G

PY - 1984/8/13

Y1 - 1984/8/13

N2 - We investigated whether administration of monosodium l-glutamate (MSG) to neonatal rats would disrupt immune responses in intact and orchidectomized adult male rats. Neonatal male rats were treated with saline or MSG which causes severe endocrine abnormalities. Half of each group of animals were orchidectomized as adults and killed one week later along with intact rats. MSG treatment resulted in suppressed serum LH levels in intact rats. Thymus weight and spleen cellularity in intact animals were not affected by MSG treatment, but thymus weight increased within one week after orchidectomy in both saline- and MSG-treated groups. In intact rats, lymphocyte stimulation by the T cell specific mitogens (concanavalin A or phytohemagglutinin) or the B cell specific mitogen (lipopolysaccharide) was unaffected by prior treatment with MSG. However, MSG treatment blocked the decrease attributable to orchidectomy in concanavalin A and phytohemagglutinin stimulation of lymphocyte blastogenesis. The results suggest that administration of MSG to neonatal male rats can alter some immune responses in the adult animal.

AB - We investigated whether administration of monosodium l-glutamate (MSG) to neonatal rats would disrupt immune responses in intact and orchidectomized adult male rats. Neonatal male rats were treated with saline or MSG which causes severe endocrine abnormalities. Half of each group of animals were orchidectomized as adults and killed one week later along with intact rats. MSG treatment resulted in suppressed serum LH levels in intact rats. Thymus weight and spleen cellularity in intact animals were not affected by MSG treatment, but thymus weight increased within one week after orchidectomy in both saline- and MSG-treated groups. In intact rats, lymphocyte stimulation by the T cell specific mitogens (concanavalin A or phytohemagglutinin) or the B cell specific mitogen (lipopolysaccharide) was unaffected by prior treatment with MSG. However, MSG treatment blocked the decrease attributable to orchidectomy in concanavalin A and phytohemagglutinin stimulation of lymphocyte blastogenesis. The results suggest that administration of MSG to neonatal male rats can alter some immune responses in the adult animal.

UR - http://www.scopus.com/inward/record.url?scp=0021144382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021144382&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(84)90349-7

DO - 10.1016/0024-3205(84)90349-7

M3 - Article

C2 - 6433129

AN - SCOPUS:0021144382

VL - 35

SP - 789

EP - 795

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 7

ER -