A cytogenetic survey of 14,069 newborn infants

I. Incidence of chromosome abnormalities

J. L. Hamerton, N. Canning, M. Ray, Shelley D Smith

Research output: Contribution to journalArticle

360 Citations (Scopus)

Abstract

Data from a chromosome examination of 14,069 consecutive newborn infants is presented. Successful karyotypes were obtained on 13,939 babies using short‐term blood culture and conventional staining methods. Of those, 13,645 babies had normal chromosomes; 64 (0.46%) had a major chromosome abnormality; and 230 (1.65%) had a marker chromosome; giving a total of 294 (2.11%) babies with a major chromosome abnormality or distinctive marker chromosomes. Six male babies with sex chromosome abnormalities had a 47, XXY and four a 47, XYY karyotype, and three were mixoploids. Five female babies had a 47, XXX karyotype and two were mixoploids. There were three babies with ambiguous external genitalia, all with normal karyotypes. Fourteen babies had 21‐trisomy; there were three 18‐trisomics and one 13‐trisomic. The mother of one 18‐trisomy baby had a balanced (18;21) translocation. Twenty‐four infants had a balanced chromosome rearrangement. Eleven of these were reciprocal and thirteen were Robertsonian translocations. One baby had an unbalanced derivative chromosome resulting from an 18;ll insertion. Two infants with additional unidentified fragments were detected. Two hundred and thirty babies (1:60) carrying distinctive chromosome variants were detected. The commonest variant was the Yq+ among males (0.89%). Other common variants involved the short arms of the D and G groups (0.32% and 0.57%, respectively) 16q+ (0.09%), and 1q+ (0.04%). The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live‐born babies. This represents a small proportion of all conceptuses with chromosome abnormalities, which has been estimated as being approximately 1:20. It is thus clear that chromosome abnormalities form a major part of the genetic load carried by the human population. The development of chromosome banding techniques already has increased, and will further increase, the complexities of human cytogenetics and may reveal many additional rearrangements undetectable by conventional methods.

Original languageEnglish (US)
Pages (from-to)223-243
Number of pages21
JournalClinical Genetics
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1975

Fingerprint

Cytogenetics
Chromosome Aberrations
Newborn Infant
Karyotype
Incidence
Chromosomes
Genetic Markers
XYY Karyotype
Sex Chromosome Aberrations
Genetic Load
Chromosome Banding
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 14
Disorders of Sex Development
Mothers
Surveys and Questionnaires
Staining and Labeling
Population

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

A cytogenetic survey of 14,069 newborn infants : I. Incidence of chromosome abnormalities. / Hamerton, J. L.; Canning, N.; Ray, M.; Smith, Shelley D.

In: Clinical Genetics, Vol. 8, No. 4, 01.01.1975, p. 223-243.

Research output: Contribution to journalArticle

Hamerton, J. L. ; Canning, N. ; Ray, M. ; Smith, Shelley D. / A cytogenetic survey of 14,069 newborn infants : I. Incidence of chromosome abnormalities. In: Clinical Genetics. 1975 ; Vol. 8, No. 4. pp. 223-243.
@article{9dbd24156dce4d068f2455db5788039b,
title = "A cytogenetic survey of 14,069 newborn infants: I. Incidence of chromosome abnormalities",
abstract = "Data from a chromosome examination of 14,069 consecutive newborn infants is presented. Successful karyotypes were obtained on 13,939 babies using short‐term blood culture and conventional staining methods. Of those, 13,645 babies had normal chromosomes; 64 (0.46{\%}) had a major chromosome abnormality; and 230 (1.65{\%}) had a marker chromosome; giving a total of 294 (2.11{\%}) babies with a major chromosome abnormality or distinctive marker chromosomes. Six male babies with sex chromosome abnormalities had a 47, XXY and four a 47, XYY karyotype, and three were mixoploids. Five female babies had a 47, XXX karyotype and two were mixoploids. There were three babies with ambiguous external genitalia, all with normal karyotypes. Fourteen babies had 21‐trisomy; there were three 18‐trisomics and one 13‐trisomic. The mother of one 18‐trisomy baby had a balanced (18;21) translocation. Twenty‐four infants had a balanced chromosome rearrangement. Eleven of these were reciprocal and thirteen were Robertsonian translocations. One baby had an unbalanced derivative chromosome resulting from an 18;ll insertion. Two infants with additional unidentified fragments were detected. Two hundred and thirty babies (1:60) carrying distinctive chromosome variants were detected. The commonest variant was the Yq+ among males (0.89{\%}). Other common variants involved the short arms of the D and G groups (0.32{\%} and 0.57{\%}, respectively) 16q+ (0.09{\%}), and 1q+ (0.04{\%}). The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live‐born babies. This represents a small proportion of all conceptuses with chromosome abnormalities, which has been estimated as being approximately 1:20. It is thus clear that chromosome abnormalities form a major part of the genetic load carried by the human population. The development of chromosome banding techniques already has increased, and will further increase, the complexities of human cytogenetics and may reveal many additional rearrangements undetectable by conventional methods.",
author = "Hamerton, {J. L.} and N. Canning and M. Ray and Smith, {Shelley D}",
year = "1975",
month = "1",
day = "1",
doi = "10.1111/j.1399-0004.1975.tb01498.x",
language = "English (US)",
volume = "8",
pages = "223--243",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - A cytogenetic survey of 14,069 newborn infants

T2 - I. Incidence of chromosome abnormalities

AU - Hamerton, J. L.

AU - Canning, N.

AU - Ray, M.

AU - Smith, Shelley D

PY - 1975/1/1

Y1 - 1975/1/1

N2 - Data from a chromosome examination of 14,069 consecutive newborn infants is presented. Successful karyotypes were obtained on 13,939 babies using short‐term blood culture and conventional staining methods. Of those, 13,645 babies had normal chromosomes; 64 (0.46%) had a major chromosome abnormality; and 230 (1.65%) had a marker chromosome; giving a total of 294 (2.11%) babies with a major chromosome abnormality or distinctive marker chromosomes. Six male babies with sex chromosome abnormalities had a 47, XXY and four a 47, XYY karyotype, and three were mixoploids. Five female babies had a 47, XXX karyotype and two were mixoploids. There were three babies with ambiguous external genitalia, all with normal karyotypes. Fourteen babies had 21‐trisomy; there were three 18‐trisomics and one 13‐trisomic. The mother of one 18‐trisomy baby had a balanced (18;21) translocation. Twenty‐four infants had a balanced chromosome rearrangement. Eleven of these were reciprocal and thirteen were Robertsonian translocations. One baby had an unbalanced derivative chromosome resulting from an 18;ll insertion. Two infants with additional unidentified fragments were detected. Two hundred and thirty babies (1:60) carrying distinctive chromosome variants were detected. The commonest variant was the Yq+ among males (0.89%). Other common variants involved the short arms of the D and G groups (0.32% and 0.57%, respectively) 16q+ (0.09%), and 1q+ (0.04%). The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live‐born babies. This represents a small proportion of all conceptuses with chromosome abnormalities, which has been estimated as being approximately 1:20. It is thus clear that chromosome abnormalities form a major part of the genetic load carried by the human population. The development of chromosome banding techniques already has increased, and will further increase, the complexities of human cytogenetics and may reveal many additional rearrangements undetectable by conventional methods.

AB - Data from a chromosome examination of 14,069 consecutive newborn infants is presented. Successful karyotypes were obtained on 13,939 babies using short‐term blood culture and conventional staining methods. Of those, 13,645 babies had normal chromosomes; 64 (0.46%) had a major chromosome abnormality; and 230 (1.65%) had a marker chromosome; giving a total of 294 (2.11%) babies with a major chromosome abnormality or distinctive marker chromosomes. Six male babies with sex chromosome abnormalities had a 47, XXY and four a 47, XYY karyotype, and three were mixoploids. Five female babies had a 47, XXX karyotype and two were mixoploids. There were three babies with ambiguous external genitalia, all with normal karyotypes. Fourteen babies had 21‐trisomy; there were three 18‐trisomics and one 13‐trisomic. The mother of one 18‐trisomy baby had a balanced (18;21) translocation. Twenty‐four infants had a balanced chromosome rearrangement. Eleven of these were reciprocal and thirteen were Robertsonian translocations. One baby had an unbalanced derivative chromosome resulting from an 18;ll insertion. Two infants with additional unidentified fragments were detected. Two hundred and thirty babies (1:60) carrying distinctive chromosome variants were detected. The commonest variant was the Yq+ among males (0.89%). Other common variants involved the short arms of the D and G groups (0.32% and 0.57%, respectively) 16q+ (0.09%), and 1q+ (0.04%). The results of the present study when combined with five other comparable studies, thus comprising a total of 46,150 newborn infants, indicates that the frequency of major chromosome abnormalities is between 1:150 and 1:200 live‐born babies. This represents a small proportion of all conceptuses with chromosome abnormalities, which has been estimated as being approximately 1:20. It is thus clear that chromosome abnormalities form a major part of the genetic load carried by the human population. The development of chromosome banding techniques already has increased, and will further increase, the complexities of human cytogenetics and may reveal many additional rearrangements undetectable by conventional methods.

UR - http://www.scopus.com/inward/record.url?scp=0016588841&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016588841&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0004.1975.tb01498.x

DO - 10.1111/j.1399-0004.1975.tb01498.x

M3 - Article

VL - 8

SP - 223

EP - 243

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 4

ER -