A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

Hui Juan Cai, Ting Ting Shen, Jian Zhang, Chang Fu Shan, Jian Guo Jia, Xiang Li, Wei Sheng Liu, Yu Tang

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

Original languageEnglish (US)
Pages (from-to)2390-2394
Number of pages5
JournalJournal of Materials Chemistry B
Volume5
Issue number13
DOIs
Publication statusPublished - Jan 1 2017

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ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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