A controlled study of peripheral neuropathy after bariatric surgery

Pariwat Thaisetthawatkul, M. L. Collazo-Clavell, M. G. Sarr, J. E. Norell, P. J B Dyck

Research output: Contribution to journalReview article

169 Citations (Scopus)

Abstract

Background: Although peripheral neuropathy (PN) occurs after bariatric surgery (BS), a causal association has not been established. Objectives: To ascertain whether PN occurs more frequently following BS vs another abdominal surgery, to characterize the clinical patterns of PN, to identify risk factors for PN, and to assess if nerve biopsy provides pathophysiologic insight. Methods: Retrospective review identified patients with PN after BS. The frequency of PN was compared with that of an age- and gender-matched, retrospectively evaluated cohort of obese patients undergoing cholecystectomy. Results: Of 435 patients who had BS, 71 (16%) developed PN. Patients developed PN more often after BS than after cholecystectomy (4/126; 3%) (p < 0.001). The clinical patterns of PN were polyneuropathy (n = 27), mononeuropathy (n = 39), and radiculoplexus neuropathy (n = 5). Risk factors included rate and absolute amount of weight loss, prolonged gastrointestinal symptoms, not attending a nutritional clinic after BS, reduced serum albumin and transferrin after BS, postoperative surgical complications requiring hospitalization, and having jejunoileal bypass. Most risk factors were associated with the polyneuropathy group. Sural nerve biopsies showed prominent axonal degeneration and perivascular inflammation. Conclusions: Peripheral neuropathy (PN) occurs more frequently after bariatric surgery (BS) than after another abdominal surgery. The three clinical patterns of PN after BS are sensory-predominant polyneuropathy, mononeuropathy, and radiculoplexus neuropathy. Malnutrition may be the most important risk factor, and patients should attend nutritional clinics. Inflammation and altered immunity may play a role in the pathogenesis, but further study is needed.

Original languageEnglish (US)
Pages (from-to)1462-1470
Number of pages9
JournalNeurology
Volume63
Issue number8
DOIs
StatePublished - Oct 26 2004

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Bariatric Surgery
Peripheral Nervous System Diseases
Polyneuropathies
Mononeuropathies
Cholecystectomy
Jejunoileal Bypass
Inflammation
Biopsy
Sural Nerve
Transferrin
Serum Albumin
Malnutrition
Weight Loss
Immunity
Hospitalization

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Thaisetthawatkul, P., Collazo-Clavell, M. L., Sarr, M. G., Norell, J. E., & Dyck, P. J. B. (2004). A controlled study of peripheral neuropathy after bariatric surgery. Neurology, 63(8), 1462-1470. https://doi.org/10.1212/01.WNL.0000142038.43946.06

A controlled study of peripheral neuropathy after bariatric surgery. / Thaisetthawatkul, Pariwat; Collazo-Clavell, M. L.; Sarr, M. G.; Norell, J. E.; Dyck, P. J B.

In: Neurology, Vol. 63, No. 8, 26.10.2004, p. 1462-1470.

Research output: Contribution to journalReview article

Thaisetthawatkul, P, Collazo-Clavell, ML, Sarr, MG, Norell, JE & Dyck, PJB 2004, 'A controlled study of peripheral neuropathy after bariatric surgery', Neurology, vol. 63, no. 8, pp. 1462-1470. https://doi.org/10.1212/01.WNL.0000142038.43946.06
Thaisetthawatkul, Pariwat ; Collazo-Clavell, M. L. ; Sarr, M. G. ; Norell, J. E. ; Dyck, P. J B. / A controlled study of peripheral neuropathy after bariatric surgery. In: Neurology. 2004 ; Vol. 63, No. 8. pp. 1462-1470.
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AU - Norell, J. E.

AU - Dyck, P. J B

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N2 - Background: Although peripheral neuropathy (PN) occurs after bariatric surgery (BS), a causal association has not been established. Objectives: To ascertain whether PN occurs more frequently following BS vs another abdominal surgery, to characterize the clinical patterns of PN, to identify risk factors for PN, and to assess if nerve biopsy provides pathophysiologic insight. Methods: Retrospective review identified patients with PN after BS. The frequency of PN was compared with that of an age- and gender-matched, retrospectively evaluated cohort of obese patients undergoing cholecystectomy. Results: Of 435 patients who had BS, 71 (16%) developed PN. Patients developed PN more often after BS than after cholecystectomy (4/126; 3%) (p < 0.001). The clinical patterns of PN were polyneuropathy (n = 27), mononeuropathy (n = 39), and radiculoplexus neuropathy (n = 5). Risk factors included rate and absolute amount of weight loss, prolonged gastrointestinal symptoms, not attending a nutritional clinic after BS, reduced serum albumin and transferrin after BS, postoperative surgical complications requiring hospitalization, and having jejunoileal bypass. Most risk factors were associated with the polyneuropathy group. Sural nerve biopsies showed prominent axonal degeneration and perivascular inflammation. Conclusions: Peripheral neuropathy (PN) occurs more frequently after bariatric surgery (BS) than after another abdominal surgery. The three clinical patterns of PN after BS are sensory-predominant polyneuropathy, mononeuropathy, and radiculoplexus neuropathy. Malnutrition may be the most important risk factor, and patients should attend nutritional clinics. Inflammation and altered immunity may play a role in the pathogenesis, but further study is needed.

AB - Background: Although peripheral neuropathy (PN) occurs after bariatric surgery (BS), a causal association has not been established. Objectives: To ascertain whether PN occurs more frequently following BS vs another abdominal surgery, to characterize the clinical patterns of PN, to identify risk factors for PN, and to assess if nerve biopsy provides pathophysiologic insight. Methods: Retrospective review identified patients with PN after BS. The frequency of PN was compared with that of an age- and gender-matched, retrospectively evaluated cohort of obese patients undergoing cholecystectomy. Results: Of 435 patients who had BS, 71 (16%) developed PN. Patients developed PN more often after BS than after cholecystectomy (4/126; 3%) (p < 0.001). The clinical patterns of PN were polyneuropathy (n = 27), mononeuropathy (n = 39), and radiculoplexus neuropathy (n = 5). Risk factors included rate and absolute amount of weight loss, prolonged gastrointestinal symptoms, not attending a nutritional clinic after BS, reduced serum albumin and transferrin after BS, postoperative surgical complications requiring hospitalization, and having jejunoileal bypass. Most risk factors were associated with the polyneuropathy group. Sural nerve biopsies showed prominent axonal degeneration and perivascular inflammation. Conclusions: Peripheral neuropathy (PN) occurs more frequently after bariatric surgery (BS) than after another abdominal surgery. The three clinical patterns of PN after BS are sensory-predominant polyneuropathy, mononeuropathy, and radiculoplexus neuropathy. Malnutrition may be the most important risk factor, and patients should attend nutritional clinics. Inflammation and altered immunity may play a role in the pathogenesis, but further study is needed.

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