A controlled seroprevalence survey of primate handlers for evidence of asymptomatic herpes b virus infection

Alison Gail Freifeld, Julia Hilliard, Janice Southers, Martha Murray, Barbara Savarese, James M. Schmitt, Stephen E. Straus

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Herpes B virus (BV) is a common cause of recurring mucocutaneous infections in monkeys of the genus Macaca. Like its human counterpart, herpes simplex virus (HSV), BV establishes lifelong latency and can be reactivated from infected monkeys symptomatically or asymptomatically. Incidental infection of humans handling BV-shedding monkeys can result in fatal meningoencephalitis. To determine whether humans exposed to infected monkeys can acquire asymptomatic BV infections, 480 subjects were evaluated in a controlled seroprevalence study. Sera from 321 primate handlers, including many with repeated injuries inflicted by Macaca monkeys, and 159 people never exposed to monkeys were tested in blinded fashion by both competition ELISA and Western blot to determine the prevalence of BV and HSV seropositivity. Although 293 persons proved positive for HSV antibodies, no primate handlers or control subjects showed BV-specific antibody responses. There is no serologic evidence that BV causes asymptomatic infections in humans.

Original languageEnglish (US)
Pages (from-to)1031-1034
Number of pages4
JournalJournal of Infectious Diseases
Volume171
Issue number4
DOIs
StatePublished - Jan 1 1995

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Cercopithecine Herpesvirus 1
Seroepidemiologic Studies
Virus Diseases
Primates
Haplorhini
Simplexvirus
Macaca
Virus Shedding
Asymptomatic Infections
Meningoencephalitis
Surveys and Questionnaires
Infection
Antibody Formation
Western Blotting
Enzyme-Linked Immunosorbent Assay
Antibodies
Wounds and Injuries

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

A controlled seroprevalence survey of primate handlers for evidence of asymptomatic herpes b virus infection. / Freifeld, Alison Gail; Hilliard, Julia; Southers, Janice; Murray, Martha; Savarese, Barbara; Schmitt, James M.; Straus, Stephen E.

In: Journal of Infectious Diseases, Vol. 171, No. 4, 01.01.1995, p. 1031-1034.

Research output: Contribution to journalArticle

Freifeld, Alison Gail ; Hilliard, Julia ; Southers, Janice ; Murray, Martha ; Savarese, Barbara ; Schmitt, James M. ; Straus, Stephen E. / A controlled seroprevalence survey of primate handlers for evidence of asymptomatic herpes b virus infection. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 4. pp. 1031-1034.
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