A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration

Xing Hui Sun, Zi Yang Liu, Hong Chen, Andrew R. Beardsley, Qi Qi, Jun Liu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Caveolin-1 (Cav-1) plays an important role in the organization of signaling molecules involved in a variety of signaling pathways, including those mediating cell motility. Here we show that amino acids K47-K57 of Cav-1 are a highly conserved sequence in Cav-1 and Cav-3 proteins, and that expression of either K47-K57 deletion Cav-1 mutant or wild-type Cav-2 that lacks this sequence exhibits a non-polarized distribution pattern. Expression of K47-K57 in Cav-2 leads to Cav-2 polarity, suggesting that expression of K47-K57 is sufficient to direct caveolin polarity. Importantly, we show that expression of this sequence is both necessary and sufficient to promote cell directional migration. Thus, our results support the conclusion that Cav-1 polarity is critical for cell directional migration.

Original languageEnglish (US)
Pages (from-to)3681-3689
Number of pages9
JournalFEBS Letters
Volume583
Issue number22
DOIs
StatePublished - Nov 19 2009

Fingerprint

Caveolins
Caveolin 1
Conserved Sequence
Cell Movement
Amino Acids
Molecules
Proteins

Keywords

  • Caveolin
  • Cell polarity
  • Directional migration

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration. / Sun, Xing Hui; Liu, Zi Yang; Chen, Hong; Beardsley, Andrew R.; Qi, Qi; Liu, Jun.

In: FEBS Letters, Vol. 583, No. 22, 19.11.2009, p. 3681-3689.

Research output: Contribution to journalArticle

Sun, Xing Hui ; Liu, Zi Yang ; Chen, Hong ; Beardsley, Andrew R. ; Qi, Qi ; Liu, Jun. / A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration. In: FEBS Letters. 2009 ; Vol. 583, No. 22. pp. 3681-3689.
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