A consensus definitive classification of scavenger receptors and their roles in health and disease

Mercy R. PrabhuDas, Cynthia L. Baldwin, Paul L. Bollyky, Dawn M.E. Bowdish, Kurt Drickamer, Maria Febbraio, Joachim Herz, Lester Kobzik, Monty Krieger, John Loike, Benita L McVicker, Terry K. Means, Soren K. Moestrup, Steven R. Post, Tatsuya Sawamura, Samuel Silverstein, Robert C. Speth, Janice C. Telfer, Geoffrey Milton Thiele, Xiang Yang WangSamuel D. Wright, Joseph El Khoury

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands including endogenous and modified host-derived molecules and microbial pathogens. There are currently eight classes of scavenger receptors, many of which have multiple names, leading to inconsistencies and confusion in the literature. To address this problem, a workshop was organized by theUnited StatesNational Institute of Allergy and Infectious Diseases, National Institutes of Health, to help develop a clear definition of scavenger receptors and a standardized nomenclature based on that definition. Fifteen experts in the scavenger receptor field attended the workshop and, after extensive discussion, reached a consensus regarding the definition of scavenger receptors and a proposed scavenger receptor nomenclature. Scavenger receptors were defined as cell surface receptors that typically bind multiple ligands and promote the removal of nonself or altered-self targets. They often function by mechanisms that include endocytosis, phagocytosis, adhesion, and signaling that ultimately lead to the elimination of degraded or harmful substances. Based on this definition, nomenclature and classification of these receptors into 10 classes were proposed. This classification was discussed at three national meetings and input from participants at these meetings was requested. The following manuscript is a consensus statement that combines the recommendations of the initial workshop and incorporates the input received from the participants at the three national meetings.

Original languageEnglish (US)
Pages (from-to)3775-3789
Number of pages15
JournalJournal of Immunology
Volume198
Issue number10
DOIs
StatePublished - May 15 2017

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Scavenger Receptors
Health
Terminology
Education
Ligands
Manuscripts
National Institutes of Health (U.S.)
Cell Surface Receptors
Myeloid Cells
Endocytosis
Phagocytosis
Names
Communicable Diseases
Hypersensitivity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

PrabhuDas, M. R., Baldwin, C. L., Bollyky, P. L., Bowdish, D. M. E., Drickamer, K., Febbraio, M., ... El Khoury, J. (2017). A consensus definitive classification of scavenger receptors and their roles in health and disease. Journal of Immunology, 198(10), 3775-3789. https://doi.org/10.4049/jimmunol.1700373

A consensus definitive classification of scavenger receptors and their roles in health and disease. / PrabhuDas, Mercy R.; Baldwin, Cynthia L.; Bollyky, Paul L.; Bowdish, Dawn M.E.; Drickamer, Kurt; Febbraio, Maria; Herz, Joachim; Kobzik, Lester; Krieger, Monty; Loike, John; McVicker, Benita L; Means, Terry K.; Moestrup, Soren K.; Post, Steven R.; Sawamura, Tatsuya; Silverstein, Samuel; Speth, Robert C.; Telfer, Janice C.; Thiele, Geoffrey Milton; Wang, Xiang Yang; Wright, Samuel D.; El Khoury, Joseph.

In: Journal of Immunology, Vol. 198, No. 10, 15.05.2017, p. 3775-3789.

Research output: Contribution to journalArticle

PrabhuDas, MR, Baldwin, CL, Bollyky, PL, Bowdish, DME, Drickamer, K, Febbraio, M, Herz, J, Kobzik, L, Krieger, M, Loike, J, McVicker, BL, Means, TK, Moestrup, SK, Post, SR, Sawamura, T, Silverstein, S, Speth, RC, Telfer, JC, Thiele, GM, Wang, XY, Wright, SD & El Khoury, J 2017, 'A consensus definitive classification of scavenger receptors and their roles in health and disease', Journal of Immunology, vol. 198, no. 10, pp. 3775-3789. https://doi.org/10.4049/jimmunol.1700373
PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M et al. A consensus definitive classification of scavenger receptors and their roles in health and disease. Journal of Immunology. 2017 May 15;198(10):3775-3789. https://doi.org/10.4049/jimmunol.1700373
PrabhuDas, Mercy R. ; Baldwin, Cynthia L. ; Bollyky, Paul L. ; Bowdish, Dawn M.E. ; Drickamer, Kurt ; Febbraio, Maria ; Herz, Joachim ; Kobzik, Lester ; Krieger, Monty ; Loike, John ; McVicker, Benita L ; Means, Terry K. ; Moestrup, Soren K. ; Post, Steven R. ; Sawamura, Tatsuya ; Silverstein, Samuel ; Speth, Robert C. ; Telfer, Janice C. ; Thiele, Geoffrey Milton ; Wang, Xiang Yang ; Wright, Samuel D. ; El Khoury, Joseph. / A consensus definitive classification of scavenger receptors and their roles in health and disease. In: Journal of Immunology. 2017 ; Vol. 198, No. 10. pp. 3775-3789.
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