A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study

MUC3 is a novel prognostic factor

Hiroaki Shibahara, Michiyo Higashi, Seiya Yokoyama, Karine Rousseau, Iwao Kitazono, Masahiko Osako, Hiroshi Shirahama, Yukie Tashiro, Yasuhiro Kurumiya, Michihiko Narita, Shingo Kuze, Hiroshi Hasagawa, Takehito Kato, Hitoshi Kubota, Hideaki Suzuki, Toshiyuki Arai, Yu Sakai, Norihiro Yuasa, Masahiko Fujino, Shinji Kondo & 14 others Yoshichika Okamoto, Tatsuyoshi Yamamoto, Takashi Hiromatsu, Eiji Sasaki, Kazuhisa Shirai, Satoru Kawai, Koutarou Hattori, Hideki Tsuji, Osamu Okochi, Masaki Sakamoto, Akinobu Kondo, Naomi Konishi, Surinder Kumar Batra, Suguru Yonezawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. Methods: Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. Results: The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p=0.036); MUC2 with histological type (mucinous carcinoma, p

Original languageEnglish (US)
Article numbere115613
JournalPLoS One
Volume9
Issue number12
DOIs
StatePublished - Dec 31 2014

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mucins
Mucins
Multicenter Studies
carcinoma
Carcinoma
Mucinous Adenocarcinoma
Colonic Neoplasms
neoplasms
Neoplasms
Immunohistochemistry
colorectal neoplasms
Tissue
immunohistochemistry
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Shibahara, H., Higashi, M., Yokoyama, S., Rousseau, K., Kitazono, I., Osako, M., ... Yonezawa, S. (2014). A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: MUC3 is a novel prognostic factor. PLoS One, 9(12), [e115613]. https://doi.org/10.1371/journal.pone.0115613

A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study : MUC3 is a novel prognostic factor. / Shibahara, Hiroaki; Higashi, Michiyo; Yokoyama, Seiya; Rousseau, Karine; Kitazono, Iwao; Osako, Masahiko; Shirahama, Hiroshi; Tashiro, Yukie; Kurumiya, Yasuhiro; Narita, Michihiko; Kuze, Shingo; Hasagawa, Hiroshi; Kato, Takehito; Kubota, Hitoshi; Suzuki, Hideaki; Arai, Toshiyuki; Sakai, Yu; Yuasa, Norihiro; Fujino, Masahiko; Kondo, Shinji; Okamoto, Yoshichika; Yamamoto, Tatsuyoshi; Hiromatsu, Takashi; Sasaki, Eiji; Shirai, Kazuhisa; Kawai, Satoru; Hattori, Koutarou; Tsuji, Hideki; Okochi, Osamu; Sakamoto, Masaki; Kondo, Akinobu; Konishi, Naomi; Batra, Surinder Kumar; Yonezawa, Suguru.

In: PLoS One, Vol. 9, No. 12, e115613, 31.12.2014.

Research output: Contribution to journalArticle

Shibahara, H, Higashi, M, Yokoyama, S, Rousseau, K, Kitazono, I, Osako, M, Shirahama, H, Tashiro, Y, Kurumiya, Y, Narita, M, Kuze, S, Hasagawa, H, Kato, T, Kubota, H, Suzuki, H, Arai, T, Sakai, Y, Yuasa, N, Fujino, M, Kondo, S, Okamoto, Y, Yamamoto, T, Hiromatsu, T, Sasaki, E, Shirai, K, Kawai, S, Hattori, K, Tsuji, H, Okochi, O, Sakamoto, M, Kondo, A, Konishi, N, Batra, SK & Yonezawa, S 2014, 'A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: MUC3 is a novel prognostic factor', PLoS One, vol. 9, no. 12, e115613. https://doi.org/10.1371/journal.pone.0115613
Shibahara, Hiroaki ; Higashi, Michiyo ; Yokoyama, Seiya ; Rousseau, Karine ; Kitazono, Iwao ; Osako, Masahiko ; Shirahama, Hiroshi ; Tashiro, Yukie ; Kurumiya, Yasuhiro ; Narita, Michihiko ; Kuze, Shingo ; Hasagawa, Hiroshi ; Kato, Takehito ; Kubota, Hitoshi ; Suzuki, Hideaki ; Arai, Toshiyuki ; Sakai, Yu ; Yuasa, Norihiro ; Fujino, Masahiko ; Kondo, Shinji ; Okamoto, Yoshichika ; Yamamoto, Tatsuyoshi ; Hiromatsu, Takashi ; Sasaki, Eiji ; Shirai, Kazuhisa ; Kawai, Satoru ; Hattori, Koutarou ; Tsuji, Hideki ; Okochi, Osamu ; Sakamoto, Masaki ; Kondo, Akinobu ; Konishi, Naomi ; Batra, Surinder Kumar ; Yonezawa, Suguru. / A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study : MUC3 is a novel prognostic factor. In: PLoS One. 2014 ; Vol. 9, No. 12.
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abstract = "Background: Mucins are implicated in survival in various cancers, but there have been no report addressed on survival in appendiceal carcinoma, an uncommon disease with different clinical and pathological features from those of other colon cancers. We aimed to investigate the clinical implications of expression of mucins in appendiceal carcinoma. Methods: Expression profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC6, MUC16 and MUC17 in cancer tissue were examined by immunohistochemistry in 108 cases of surgically resected appendiceal carcinoma. Results: The following relationships of mucins with clinicopathologic factors were identified: MUC1 with positive lymphatic invasion (p=0.036); MUC2 with histological type (mucinous carcinoma, p",
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AU - Shibahara, Hiroaki

AU - Higashi, Michiyo

AU - Yokoyama, Seiya

AU - Rousseau, Karine

AU - Kitazono, Iwao

AU - Osako, Masahiko

AU - Shirahama, Hiroshi

AU - Tashiro, Yukie

AU - Kurumiya, Yasuhiro

AU - Narita, Michihiko

AU - Kuze, Shingo

AU - Hasagawa, Hiroshi

AU - Kato, Takehito

AU - Kubota, Hitoshi

AU - Suzuki, Hideaki

AU - Arai, Toshiyuki

AU - Sakai, Yu

AU - Yuasa, Norihiro

AU - Fujino, Masahiko

AU - Kondo, Shinji

AU - Okamoto, Yoshichika

AU - Yamamoto, Tatsuyoshi

AU - Hiromatsu, Takashi

AU - Sasaki, Eiji

AU - Shirai, Kazuhisa

AU - Kawai, Satoru

AU - Hattori, Koutarou

AU - Tsuji, Hideki

AU - Okochi, Osamu

AU - Sakamoto, Masaki

AU - Kondo, Akinobu

AU - Konishi, Naomi

AU - Batra, Surinder Kumar

AU - Yonezawa, Suguru

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