A composite disease activity scale for clinical practice, observational studies, and clinical trials: The patient activity scale (PAS/PAS-II)

Frederick Wolfe, Kaleb Michaud, Theodore Pincus

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Objective. To develop and validate a composite patient self-report disease activity scale for use in clinical practice and in observational studies and clinical trials. Methods. A total of 9078 patients with rheumatoid arthritis completed detailed questionnaires that included measure of quality of life in the form of utilities. We evaluated several disease activity scales by measuring their agreement with the utility scales, and also their assessed ability to predict mortality and prescription for anti-tumor necrosis factor therapy. Results. A composite index composed of a visual analog scale (VAS) for pain, a patient global VAS, and the Health Assessment Questionnaire (HAQ) or the HAQ II formed the Patient Activity Scale (PAS) and PAS-II. These scales performed as well as or better than longer, more complex scales. Conclusion. A simple, useful clinical scale, the PAS or PAS-II, can be formed by the use of common clinical variables. It is well correlated with and relevant to a wide range of clinical variables. This scale should be useful for comparative studies, clinical care, and regulatory documentation.

Original languageEnglish (US)
Pages (from-to)2410-2415
Number of pages6
JournalJournal of Rheumatology
Volume32
Issue number12
StatePublished - Dec 1 2005

Fingerprint

Observational Studies
Clinical Trials
Health
Pain Measurement
Visual Analog Scale
Documentation
Self Report
Prescriptions
Rheumatoid Arthritis
Tumor Necrosis Factor-alpha
Quality of Life
Mortality
Surveys and Questionnaires

Keywords

  • Disease activity
  • Health assessment questionnaire
  • Patient activity scale
  • Visual analog scale

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

A composite disease activity scale for clinical practice, observational studies, and clinical trials : The patient activity scale (PAS/PAS-II). / Wolfe, Frederick; Michaud, Kaleb; Pincus, Theodore.

In: Journal of Rheumatology, Vol. 32, No. 12, 01.12.2005, p. 2410-2415.

Research output: Contribution to journalArticle

@article{6f0a56ca1e2b496bbebdb3f22ff1b2e0,
title = "A composite disease activity scale for clinical practice, observational studies, and clinical trials: The patient activity scale (PAS/PAS-II)",
abstract = "Objective. To develop and validate a composite patient self-report disease activity scale for use in clinical practice and in observational studies and clinical trials. Methods. A total of 9078 patients with rheumatoid arthritis completed detailed questionnaires that included measure of quality of life in the form of utilities. We evaluated several disease activity scales by measuring their agreement with the utility scales, and also their assessed ability to predict mortality and prescription for anti-tumor necrosis factor therapy. Results. A composite index composed of a visual analog scale (VAS) for pain, a patient global VAS, and the Health Assessment Questionnaire (HAQ) or the HAQ II formed the Patient Activity Scale (PAS) and PAS-II. These scales performed as well as or better than longer, more complex scales. Conclusion. A simple, useful clinical scale, the PAS or PAS-II, can be formed by the use of common clinical variables. It is well correlated with and relevant to a wide range of clinical variables. This scale should be useful for comparative studies, clinical care, and regulatory documentation.",
keywords = "Disease activity, Health assessment questionnaire, Patient activity scale, Visual analog scale",
author = "Frederick Wolfe and Kaleb Michaud and Theodore Pincus",
year = "2005",
month = "12",
day = "1",
language = "English (US)",
volume = "32",
pages = "2410--2415",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "12",

}

TY - JOUR

T1 - A composite disease activity scale for clinical practice, observational studies, and clinical trials

T2 - The patient activity scale (PAS/PAS-II)

AU - Wolfe, Frederick

AU - Michaud, Kaleb

AU - Pincus, Theodore

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Objective. To develop and validate a composite patient self-report disease activity scale for use in clinical practice and in observational studies and clinical trials. Methods. A total of 9078 patients with rheumatoid arthritis completed detailed questionnaires that included measure of quality of life in the form of utilities. We evaluated several disease activity scales by measuring their agreement with the utility scales, and also their assessed ability to predict mortality and prescription for anti-tumor necrosis factor therapy. Results. A composite index composed of a visual analog scale (VAS) for pain, a patient global VAS, and the Health Assessment Questionnaire (HAQ) or the HAQ II formed the Patient Activity Scale (PAS) and PAS-II. These scales performed as well as or better than longer, more complex scales. Conclusion. A simple, useful clinical scale, the PAS or PAS-II, can be formed by the use of common clinical variables. It is well correlated with and relevant to a wide range of clinical variables. This scale should be useful for comparative studies, clinical care, and regulatory documentation.

AB - Objective. To develop and validate a composite patient self-report disease activity scale for use in clinical practice and in observational studies and clinical trials. Methods. A total of 9078 patients with rheumatoid arthritis completed detailed questionnaires that included measure of quality of life in the form of utilities. We evaluated several disease activity scales by measuring their agreement with the utility scales, and also their assessed ability to predict mortality and prescription for anti-tumor necrosis factor therapy. Results. A composite index composed of a visual analog scale (VAS) for pain, a patient global VAS, and the Health Assessment Questionnaire (HAQ) or the HAQ II formed the Patient Activity Scale (PAS) and PAS-II. These scales performed as well as or better than longer, more complex scales. Conclusion. A simple, useful clinical scale, the PAS or PAS-II, can be formed by the use of common clinical variables. It is well correlated with and relevant to a wide range of clinical variables. This scale should be useful for comparative studies, clinical care, and regulatory documentation.

KW - Disease activity

KW - Health assessment questionnaire

KW - Patient activity scale

KW - Visual analog scale

UR - http://www.scopus.com/inward/record.url?scp=28844462684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28844462684&partnerID=8YFLogxK

M3 - Article

C2 - 16331773

AN - SCOPUS:28844462684

VL - 32

SP - 2410

EP - 2415

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 12

ER -