A comparison of transcranial doppler ultrasound (TCD) and radioactive microspheres in determining cerebral perfusion in normal and low flow states

Lawrence M. Lewis, Joseph C. Stothert, Gary E. Kraus, Camilo R. Gomez, Henry Goodgold, Raymond M. Keltner, Kenneth Ashley, John P. Fortney

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have previously utilized the technique of transcranial Doppler (TCD) ultrasound to determine cerebral perfusion in patients undergoing cardiopulmonary resuscitation (CPR). In order to assess if TCD can reliably measure alterations in cerebral perfusion under conditions of normal and low cardiac outputs, we compared TCD measured blood flow velocities in the middle cerebral artery (MCA) of six piglets with radioactive microsphere determinations of total cerebral perfusion at baseline normal sinus rhythm (NSR), during CPR, and following return of spontaneous circulation (ROSC). Peak systolic and mean blood flow velocities were compared to the microsphere perfusion results on 15 different occasions; six during NSR, five during CPR, and four following ROSC. Although qualitative alterations in TCD measurements reflected changes in microsphere perfusion, we could not find a statistically significant correlation between either peak systolic or mean MCA blood flow velocities and microsphere perfusion measurements either overall or in any subgroup. The possible reasons which may explain the findings are discussed.

Original languageEnglish (US)
Pages (from-to)213-220
Number of pages8
JournalResuscitation
Volume20
Issue number3
DOIs
StatePublished - Dec 1990

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Doppler Ultrasonography
Microspheres
Perfusion
Blood Flow Velocity
Cardiopulmonary Resuscitation
Middle Cerebral Artery
Cerebrovascular Circulation
Low Cardiac Output

Keywords

  • Cardiopulmonary resuscitation
  • Cerebral perfusion
  • Doppler
  • Transcranial

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Cite this

A comparison of transcranial doppler ultrasound (TCD) and radioactive microspheres in determining cerebral perfusion in normal and low flow states. / Lewis, Lawrence M.; Stothert, Joseph C.; Kraus, Gary E.; Gomez, Camilo R.; Goodgold, Henry; Keltner, Raymond M.; Ashley, Kenneth; Fortney, John P.

In: Resuscitation, Vol. 20, No. 3, 12.1990, p. 213-220.

Research output: Contribution to journalArticle

Lewis, Lawrence M. ; Stothert, Joseph C. ; Kraus, Gary E. ; Gomez, Camilo R. ; Goodgold, Henry ; Keltner, Raymond M. ; Ashley, Kenneth ; Fortney, John P. / A comparison of transcranial doppler ultrasound (TCD) and radioactive microspheres in determining cerebral perfusion in normal and low flow states. In: Resuscitation. 1990 ; Vol. 20, No. 3. pp. 213-220.
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