A comparison of the effects of sodium saccharin in NBR rats and in intact and castrated male F344 rats

Emily M. Garland, Margaret St John, Makoto Asamoto, Steven H. Eklund, Barbara J. Mattson, Linda S. Johnson, Martin Cano, Samuel Monroe Cohen

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High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that α2u-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived α2u-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary α2u-globulin levels.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalCancer Letters
Issue number1-3
Publication statusPublished - Apr 1 1994



  • Bladder
  • Proliferation
  • Rat
  • Saccharin
  • α-Globulin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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