A challenge for regenerative medicine: Proper genetic programming, not cellular mimicry

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Recent progress in stem cell biology and the reprogramming of somatic cells to a pluripotent phenotype has generated a new wave of excitement in regenerative medicine. Nonetheless, efforts aimed at understanding transdifferentiation, dedifferentiation, and the plasticity of cells, as well as the ability of somatic cells to be reprogrammed, has raised as many questions as those that have been answered. This review proffers the argument that many reports of transdifferentiation, dedifferentiation, and unexpected stem cell plasticity may be due to aberrant processes that lead to cellular look-alikes (cellular mimicry). In most cases, cellular look-alikes can now be identified readily by monitoring gene expression profiles, as well as epigenetic modifications of DNA and histone proteins of the cells involved. This review further argues that progress in regenerative medicine will be significantly hampered by failing to address the issue of cellular look-alikes.

Original languageEnglish (US)
Pages (from-to)3199-3207
Number of pages9
JournalDevelopmental Dynamics
Volume236
Issue number12
DOIs
StatePublished - Dec 1 2007

Fingerprint

Regenerative Medicine
Stem Cells
Histone Code
Cell Dedifferentiation
Transcriptome
Epigenomics
Cell Biology
Phenotype
DNA
Proteins
Cell Plasticity

Keywords

  • Cellular mimicry
  • Cellular mosaic
  • Dedifferentiation
  • Differentiation
  • Embryonic stem cells
  • Epigenetic
  • Hematopoietic stem cells
  • Histone modification
  • Regeneration
  • Reprogramming
  • Stem cells
  • Transdifferentiation

ASJC Scopus subject areas

  • Developmental Biology

Cite this

A challenge for regenerative medicine : Proper genetic programming, not cellular mimicry. / Rizzino, A Angie.

In: Developmental Dynamics, Vol. 236, No. 12, 01.12.2007, p. 3199-3207.

Research output: Contribution to journalReview article

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