A Cellular Dynamics Model of Experimental Bladder Cancer: Analysis of the Effect of Sodium Saccharin in the Rat

L. B. Ellwein, Samuel Monroe Cohen

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

To make the methodology of risk assessment more consistent with the realities of biological processes, a computer‐based model of the carcinogenic process may be used. A previously developed probabilistic model, which is based on a two‐stage theory of carcinogenesis, represents urinary bladder carcinogenesis at the cellular level with emphasis on quantification of cell dynamics: cell mitotic rates, cell loss and birth rates, and irreversible cellular transitions from normal to initiated to transformed states are explicitly accounted for. Analyses demonstrate the sensitivity of tumor incidence to the timing and magnitude of changes to these cellular variables. It is demonstrated that response in rats following administration of nongenotoxic compounds, such as sodium saccharin, can be explained entirely on the basis of cytotoxicity and consequent hyperplasia alone.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalRisk Analysis
Volume8
Issue number2
DOIs
StatePublished - Jun 1988

Fingerprint

Saccharin
Cytotoxicity
Urinary Bladder Neoplasms
Risk assessment
Rats
Tumors
Dynamic models
Theoretical Models
Sodium
Carcinogenesis
Biological Phenomena
Birth Rate
Statistical Models
Hyperplasia
Urinary Bladder
Incidence
Neoplasms

Keywords

  • Computer modeling
  • bladder carcinogenesis
  • cell dynamics
  • risk assessment

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Physiology (medical)

Cite this

A Cellular Dynamics Model of Experimental Bladder Cancer : Analysis of the Effect of Sodium Saccharin in the Rat. / Ellwein, L. B.; Cohen, Samuel Monroe.

In: Risk Analysis, Vol. 8, No. 2, 06.1988, p. 215-221.

Research output: Contribution to journalArticle

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