A 21st century roadmap for human health risk assessment

Timothy P. Pastoor, Ammie N. Bachman, David R. Bell, Samuel Monroe Cohen, Michael Dellarco, Ian C. Dewhurst, John E. Doe, Nancy G. Doerrer, Michelle R. Embry, Ronald N. Hines, Angelo Moretto, Richard D. Phillips, J. Craig Rowlands, Jennifer Y. Tanir, Douglas C. Wolf, Alan R. Boobis

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government institutions, 20 universities, 2 non-governmental organizations, and 12 corporations. This paper provides a brief overview of the tiered RISK21 framework called the roadmap and risk visualization matrix, and articulates the core principles derived by RISK21 participants that guided its development. Subsequent papers describe the roadmap and matrix in greater detail. RISK21 principles include focusing on problem formulation, utilizing existing information, starting with exposure assessment (rather than toxicity), and using a tiered process for data development. Bringing estimates of exposure and toxicity together on a two-dimensional matrix provides a clear rendition of human safety and risk. The value of the roadmap is its capacity to chronicle the stepwise acquisition of scientific information and display it in a clear and concise fashion. Furthermore, the tiered approach and transparent display of information will contribute to greater efficiencies by calling for data only as needed (enough precision to make a decision), thus conserving animals and other resources.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalCritical reviews in toxicology
Volume44
Issue numberSUPPL.3
DOIs
StatePublished - Aug 2014

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Data Display
Health risks
Risk assessment
Toxicity
Environmental Health
Health
Research Design
Organizations
Efficiency
Safety
Animals
Visualization
Display devices
Industry
Global Health

Keywords

  • Exposure
  • Framework
  • Hazard
  • Problem formulation
  • Risk
  • Risk assessment
  • Risk policy
  • Tiered

ASJC Scopus subject areas

  • Toxicology

Cite this

Pastoor, T. P., Bachman, A. N., Bell, D. R., Cohen, S. M., Dellarco, M., Dewhurst, I. C., ... Boobis, A. R. (2014). A 21st century roadmap for human health risk assessment. Critical reviews in toxicology, 44(SUPPL.3), 1-5. https://doi.org/10.3109/10408444.2014.931923

A 21st century roadmap for human health risk assessment. / Pastoor, Timothy P.; Bachman, Ammie N.; Bell, David R.; Cohen, Samuel Monroe; Dellarco, Michael; Dewhurst, Ian C.; Doe, John E.; Doerrer, Nancy G.; Embry, Michelle R.; Hines, Ronald N.; Moretto, Angelo; Phillips, Richard D.; Rowlands, J. Craig; Tanir, Jennifer Y.; Wolf, Douglas C.; Boobis, Alan R.

In: Critical reviews in toxicology, Vol. 44, No. SUPPL.3, 08.2014, p. 1-5.

Research output: Contribution to journalReview article

Pastoor, TP, Bachman, AN, Bell, DR, Cohen, SM, Dellarco, M, Dewhurst, IC, Doe, JE, Doerrer, NG, Embry, MR, Hines, RN, Moretto, A, Phillips, RD, Rowlands, JC, Tanir, JY, Wolf, DC & Boobis, AR 2014, 'A 21st century roadmap for human health risk assessment', Critical reviews in toxicology, vol. 44, no. SUPPL.3, pp. 1-5. https://doi.org/10.3109/10408444.2014.931923
Pastoor TP, Bachman AN, Bell DR, Cohen SM, Dellarco M, Dewhurst IC et al. A 21st century roadmap for human health risk assessment. Critical reviews in toxicology. 2014 Aug;44(SUPPL.3):1-5. https://doi.org/10.3109/10408444.2014.931923
Pastoor, Timothy P. ; Bachman, Ammie N. ; Bell, David R. ; Cohen, Samuel Monroe ; Dellarco, Michael ; Dewhurst, Ian C. ; Doe, John E. ; Doerrer, Nancy G. ; Embry, Michelle R. ; Hines, Ronald N. ; Moretto, Angelo ; Phillips, Richard D. ; Rowlands, J. Craig ; Tanir, Jennifer Y. ; Wolf, Douglas C. ; Boobis, Alan R. / A 21st century roadmap for human health risk assessment. In: Critical reviews in toxicology. 2014 ; Vol. 44, No. SUPPL.3. pp. 1-5.
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