7-OH-DPAT has d-amphetamine-like discriminative stimulus properties

Rick A Bevins, Jennifer E. Klebaur, Michael T. Bardo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreased as the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (±)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties with the amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume58
Issue number2
DOIs
StatePublished - Oct 1 1997

Fingerprint

Dextroamphetamine
eticlopride
Dopamine D3 Receptors
Substitution reactions
Amphetamine
Dopamine D2 Receptors
Dopamine
Rats
Food
7-hydroxy-2-N,N-dipropylaminotetralin
hydroxide ion
Pharmaceutical Preparations

Keywords

  • Amphetamine
  • D2 and D3 receptors
  • Dopamine
  • Drug discrimination
  • Eticlopride
  • Operant conditioning

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

7-OH-DPAT has d-amphetamine-like discriminative stimulus properties. / Bevins, Rick A; Klebaur, Jennifer E.; Bardo, Michael T.

In: Pharmacology Biochemistry and Behavior, Vol. 58, No. 2, 01.10.1997, p. 485-490.

Research output: Contribution to journalArticle

Bevins, Rick A ; Klebaur, Jennifer E. ; Bardo, Michael T. / 7-OH-DPAT has d-amphetamine-like discriminative stimulus properties. In: Pharmacology Biochemistry and Behavior. 1997 ; Vol. 58, No. 2. pp. 485-490.
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