7-OH-DPAT has d-amphetamine-like discriminative stimulus properties

Rick A. Bevins, Jennifer E. Klebaur, Michael T. Bardo

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreased as the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (±)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties with the amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume58
Issue number2
DOIs
StatePublished - Oct 1 1997

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Keywords

  • Amphetamine
  • D2 and D3 receptors
  • Dopamine
  • Drug discrimination
  • Eticlopride
  • Operant conditioning

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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