4SC-202 as a potential treatment for the pediatric brain tumor medulloblastoma

Shanta M. Messerli, Mariah M. Hoffman, Etienne Z. Gnimpieba, Hella Kohlhof, Ratan D. Bhardwaj

Research output: Contribution to journalArticle

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Abstract

This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).

Original languageEnglish (US)
Article number147
JournalBrain Sciences
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2017

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Keywords

  • 4SC-202
  • Bioinformatics
  • Medulloblastoma
  • Microarray
  • Pediatric brain tumor

ASJC Scopus subject areas

  • Neuroscience(all)

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