3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis

Ali Farzin, Amir K. Miri, Fatemeh Sharifi, Negar Faramarzi, Arian Jaberi, Azadeh Mostafavi, Ricky Solorzano, Yu Shrike Zhang, Nasim Annabi, Ali Khademhosseini, Ali Tamayol

Research output: Contribution to journalArticle

Abstract

Microvascular anastomosis is a common part of many reconstructive and transplant surgical procedures. While venous anastomosis can be achieved using microvascular anastomotic coupling devices, surgical suturing is the main method for arterial anastomosis. Suture-based microanastomosis is time-consuming and challenging. Here, dissolvable sugar-based stents are fabricated as an assistive tool for facilitating surgical anastomosis. The nonbrittle sugar-based stent holds the vessels together during the procedure and are dissolved upon the restoration of the blood flow. The incorporation of sodium citrate minimizes the chance of thrombosis. The dissolution rate and the mechanical properties of the sugar-based stent can be tailored between 4 and 8 min. To enable the fabrication of stents with desirable geometries and dimensions, 3D printing is utilized to fabricate the stents. The effectiveness of the printed sugar-based stent is assessed ex vivo. The fabrication procedure is fast and can be performed in the operating room.

LanguageEnglish (US)
Article number1800702
JournalAdvanced Healthcare Materials
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Stents
Sugars
Blood Vessels
Reconstructive Surgical Procedures
Surgical Anastomosis
Operating rooms
Fabrication
Transplants
Operating Rooms
Sutures
Restoration
Printing
Dissolution
Thrombosis
Blood
Sodium
Equipment and Supplies
Mechanical properties
Geometry

Keywords

  • 3D printing
  • dissolvable stents
  • personalized surgical tools
  • sugar-based materials
  • vascular anastomosis

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Farzin, A., Miri, A. K., Sharifi, F., Faramarzi, N., Jaberi, A., Mostafavi, A., ... Tamayol, A. (Accepted/In press). 3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis. Advanced Healthcare Materials, [1800702]. https://doi.org/10.1002/adhm.201800702

3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis. / Farzin, Ali; Miri, Amir K.; Sharifi, Fatemeh; Faramarzi, Negar; Jaberi, Arian; Mostafavi, Azadeh; Solorzano, Ricky; Zhang, Yu Shrike; Annabi, Nasim; Khademhosseini, Ali; Tamayol, Ali.

In: Advanced Healthcare Materials, 01.01.2018.

Research output: Contribution to journalArticle

Farzin, A, Miri, AK, Sharifi, F, Faramarzi, N, Jaberi, A, Mostafavi, A, Solorzano, R, Zhang, YS, Annabi, N, Khademhosseini, A & Tamayol, A 2018, '3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis' Advanced Healthcare Materials. https://doi.org/10.1002/adhm.201800702
Farzin A, Miri AK, Sharifi F, Faramarzi N, Jaberi A, Mostafavi A et al. 3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis. Advanced Healthcare Materials. 2018 Jan 1. 1800702. https://doi.org/10.1002/adhm.201800702
Farzin, Ali ; Miri, Amir K. ; Sharifi, Fatemeh ; Faramarzi, Negar ; Jaberi, Arian ; Mostafavi, Azadeh ; Solorzano, Ricky ; Zhang, Yu Shrike ; Annabi, Nasim ; Khademhosseini, Ali ; Tamayol, Ali. / 3D-Printed Sugar-Based Stents Facilitating Vascular Anastomosis. In: Advanced Healthcare Materials. 2018.
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