3D Printed Anchoring Sutures for Permanent Shaping of Tissues

Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol, Yu Shrike Zhang, Ali Khademhosseini, Hae Lin Jang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while maximizing its resistive force against the opposite direction of external force to lock its position in tissues. Different microstructures of suture anchors are systematically designed using orthogonal arrays, and selected based on shape factors associated with mechanical strength. 3D printing is used to fabricate different types of hollow microstructured suture anchors, and optimize their structure for the effective shaping of tissues. To define the structural design for fixing tissues, the maximum force required to pull 3D printed anchors in different directions is examined with tissues. The tissue reshaping function of suture anchors is further simulated ex vivo by using swine ear, nose, and skin, and bovine muscle tendon. This study provides advantages for building functional sutures that can be used for permanently reshaping tissues with enhanced mechanical strength, eliminating the need for knotting to improve surgical efficiency.

Original languageEnglish (US)
Article number1700304
JournalMacromolecular Bioscience
Volume17
Issue number12
DOIs
StatePublished - Dec 2017

Fingerprint

Sutures
Tissue
Suture Anchors
Anchors
Strength of materials
Tendons
Structural design
Nose
Surgery
Ear
Muscle
Printing
Skin
Swine
Inflammation
Efficiency
Equipment and Supplies
Muscles
Microstructure
Wounds and Injuries

Keywords

  • 3D printing
  • anchoring suture
  • minimally invasive treatment
  • reconstructive surgery
  • tissue reshaping

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Wei, W., Li, Y., Yang, H., Nassab, R., Shahriyari, F., Akpek, A., ... Jang, H. L. (2017). 3D Printed Anchoring Sutures for Permanent Shaping of Tissues. Macromolecular Bioscience, 17(12), [1700304]. https://doi.org/10.1002/mabi.201700304

3D Printed Anchoring Sutures for Permanent Shaping of Tissues. / Wei, Wei; Li, Yuxiao; Yang, Huazhe; Nassab, Reza; Shahriyari, Fatemeh; Akpek, Ali; Guan, Xiaofei; Liu, Yanhui; Taranejoo, Shahrouz; Tamayol, Ali; Zhang, Yu Shrike; Khademhosseini, Ali; Jang, Hae Lin.

In: Macromolecular Bioscience, Vol. 17, No. 12, 1700304, 12.2017.

Research output: Contribution to journalArticle

Wei, W, Li, Y, Yang, H, Nassab, R, Shahriyari, F, Akpek, A, Guan, X, Liu, Y, Taranejoo, S, Tamayol, A, Zhang, YS, Khademhosseini, A & Jang, HL 2017, '3D Printed Anchoring Sutures for Permanent Shaping of Tissues', Macromolecular Bioscience, vol. 17, no. 12, 1700304. https://doi.org/10.1002/mabi.201700304
Wei W, Li Y, Yang H, Nassab R, Shahriyari F, Akpek A et al. 3D Printed Anchoring Sutures for Permanent Shaping of Tissues. Macromolecular Bioscience. 2017 Dec;17(12). 1700304. https://doi.org/10.1002/mabi.201700304
Wei, Wei ; Li, Yuxiao ; Yang, Huazhe ; Nassab, Reza ; Shahriyari, Fatemeh ; Akpek, Ali ; Guan, Xiaofei ; Liu, Yanhui ; Taranejoo, Shahrouz ; Tamayol, Ali ; Zhang, Yu Shrike ; Khademhosseini, Ali ; Jang, Hae Lin. / 3D Printed Anchoring Sutures for Permanent Shaping of Tissues. In: Macromolecular Bioscience. 2017 ; Vol. 17, No. 12.
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