3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation

Bin Duan, Shaohua Wu, Mitchell Kuss, Philipp N Streubel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Rotator cuff tendon tears are one of the leading causes of debilitating shoulder pain in the United States. The use of grafts has been studied in the past for reconstruction of such non-repairable tears or to augment repairable tears of large size. Unfortunately, current treatment strategies, including auto-, allo-and xenografts as well as synthetic implants, fail to restore the functional, structural, and biochemical properties of repaired rotator cuff to those of native tissue, with overall failure rate between 38% and 65%. Rotator cuff tendon exhibits distinct transition zones from the musculotendinous region to tendon to fibrocartilage to bone. Each zone has a distinct degree of vascularization. Current augmentation options fail to mimic these transition zones, due to their homogeneous architectural structure. In this study, we combined 3D bioprinting technique with textile technique to generate biomimetic constructs with spatial control of vascularization for massive rotator cuff repair in a rabbit model.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Bioprinting
Biomimetics
Rotator Cuff
Tendons
Tears
Fibrocartilage
Shoulder Pain
Textiles
Heterografts
Grafts
Bone
Repair
Tissue
Rabbits
Transplants
Bone and Bones

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Duan, B., Wu, S., Kuss, M., & Streubel, P. N. (2019). 3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation. / Duan, Bin; Wu, Shaohua; Kuss, Mitchell; Streubel, Philipp N.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Duan, B, Wu, S, Kuss, M & Streubel, PN 2019, 3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Duan B, Wu S, Kuss M, Streubel PN. 3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Duan, Bin ; Wu, Shaohua ; Kuss, Mitchell ; Streubel, Philipp N. / 3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
@inproceedings{3d7221d359f94eaf97365ee6ecc8afea,
title = "3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation",
abstract = "Statement of Purpose: Rotator cuff tendon tears are one of the leading causes of debilitating shoulder pain in the United States. The use of grafts has been studied in the past for reconstruction of such non-repairable tears or to augment repairable tears of large size. Unfortunately, current treatment strategies, including auto-, allo-and xenografts as well as synthetic implants, fail to restore the functional, structural, and biochemical properties of repaired rotator cuff to those of native tissue, with overall failure rate between 38{\%} and 65{\%}. Rotator cuff tendon exhibits distinct transition zones from the musculotendinous region to tendon to fibrocartilage to bone. Each zone has a distinct degree of vascularization. Current augmentation options fail to mimic these transition zones, due to their homogeneous architectural structure. In this study, we combined 3D bioprinting technique with textile technique to generate biomimetic constructs with spatial control of vascularization for massive rotator cuff repair in a rabbit model.",
author = "Bin Duan and Shaohua Wu and Mitchell Kuss and Streubel, {Philipp N}",
year = "2019",
month = "1",
day = "1",
language = "English (US)",
series = "Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium",
publisher = "Society for Biomaterials",
booktitle = "Society for Biomaterials Annual Meeting and Exposition 2019",

}

TY - GEN

T1 - 3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation

AU - Duan, Bin

AU - Wu, Shaohua

AU - Kuss, Mitchell

AU - Streubel, Philipp N

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Statement of Purpose: Rotator cuff tendon tears are one of the leading causes of debilitating shoulder pain in the United States. The use of grafts has been studied in the past for reconstruction of such non-repairable tears or to augment repairable tears of large size. Unfortunately, current treatment strategies, including auto-, allo-and xenografts as well as synthetic implants, fail to restore the functional, structural, and biochemical properties of repaired rotator cuff to those of native tissue, with overall failure rate between 38% and 65%. Rotator cuff tendon exhibits distinct transition zones from the musculotendinous region to tendon to fibrocartilage to bone. Each zone has a distinct degree of vascularization. Current augmentation options fail to mimic these transition zones, due to their homogeneous architectural structure. In this study, we combined 3D bioprinting technique with textile technique to generate biomimetic constructs with spatial control of vascularization for massive rotator cuff repair in a rabbit model.

AB - Statement of Purpose: Rotator cuff tendon tears are one of the leading causes of debilitating shoulder pain in the United States. The use of grafts has been studied in the past for reconstruction of such non-repairable tears or to augment repairable tears of large size. Unfortunately, current treatment strategies, including auto-, allo-and xenografts as well as synthetic implants, fail to restore the functional, structural, and biochemical properties of repaired rotator cuff to those of native tissue, with overall failure rate between 38% and 65%. Rotator cuff tendon exhibits distinct transition zones from the musculotendinous region to tendon to fibrocartilage to bone. Each zone has a distinct degree of vascularization. Current augmentation options fail to mimic these transition zones, due to their homogeneous architectural structure. In this study, we combined 3D bioprinting technique with textile technique to generate biomimetic constructs with spatial control of vascularization for massive rotator cuff repair in a rabbit model.

UR - http://www.scopus.com/inward/record.url?scp=85065406461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065406461&partnerID=8YFLogxK

M3 - Conference contribution

T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

BT - Society for Biomaterials Annual Meeting and Exposition 2019

PB - Society for Biomaterials

ER -