Abstract
Statement of Purpose: Rotator cuff tendon tears are one of the leading causes of debilitating shoulder pain in the United States. The use of grafts has been studied in the past for reconstruction of such non-repairable tears or to augment repairable tears of large size. Unfortunately, current treatment strategies, including auto-, allo-and xenografts as well as synthetic implants, fail to restore the functional, structural, and biochemical properties of repaired rotator cuff to those of native tissue, with overall failure rate between 38% and 65%. Rotator cuff tendon exhibits distinct transition zones from the musculotendinous region to tendon to fibrocartilage to bone. Each zone has a distinct degree of vascularization. Current augmentation options fail to mimic these transition zones, due to their homogeneous architectural structure. In this study, we combined 3D bioprinting technique with textile technique to generate biomimetic constructs with spatial control of vascularization for massive rotator cuff repair in a rabbit model.
| Original language | English (US) |
|---|---|
| Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 |
| Subtitle of host publication | The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
| Publisher | Society for Biomaterials |
| Number of pages | 1 |
| ISBN (Electronic) | 9781510883901 |
| State | Published - Jan 1 2019 |
| Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: Apr 3 2019 → Apr 6 2019 |
Publication series
| Name | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
|---|---|
| Volume | 40 |
| ISSN (Print) | 1526-7547 |
Conference
| Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
|---|---|
| Country | United States |
| City | Seattle |
| Period | 4/3/19 → 4/6/19 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Biotechnology
- Biomaterials
- Materials Chemistry
Cite this
3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation. / Duan, Bin; Wu, Shaohua; Kuss, Mitchell; Streubel, Philipp N.
Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - 3d bioprinting of biomimetic constructs with spatially controlled microenvironment for rotator cuff augmentation
AU - Duan, Bin
AU - Wu, Shaohua
AU - Kuss, Mitchell
AU - Streubel, Philipp N
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Statement of Purpose: Rotator cuff tendon tears are one of the leading causes of debilitating shoulder pain in the United States. The use of grafts has been studied in the past for reconstruction of such non-repairable tears or to augment repairable tears of large size. Unfortunately, current treatment strategies, including auto-, allo-and xenografts as well as synthetic implants, fail to restore the functional, structural, and biochemical properties of repaired rotator cuff to those of native tissue, with overall failure rate between 38% and 65%. Rotator cuff tendon exhibits distinct transition zones from the musculotendinous region to tendon to fibrocartilage to bone. Each zone has a distinct degree of vascularization. Current augmentation options fail to mimic these transition zones, due to their homogeneous architectural structure. In this study, we combined 3D bioprinting technique with textile technique to generate biomimetic constructs with spatial control of vascularization for massive rotator cuff repair in a rabbit model.
AB - Statement of Purpose: Rotator cuff tendon tears are one of the leading causes of debilitating shoulder pain in the United States. The use of grafts has been studied in the past for reconstruction of such non-repairable tears or to augment repairable tears of large size. Unfortunately, current treatment strategies, including auto-, allo-and xenografts as well as synthetic implants, fail to restore the functional, structural, and biochemical properties of repaired rotator cuff to those of native tissue, with overall failure rate between 38% and 65%. Rotator cuff tendon exhibits distinct transition zones from the musculotendinous region to tendon to fibrocartilage to bone. Each zone has a distinct degree of vascularization. Current augmentation options fail to mimic these transition zones, due to their homogeneous architectural structure. In this study, we combined 3D bioprinting technique with textile technique to generate biomimetic constructs with spatial control of vascularization for massive rotator cuff repair in a rabbit model.
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UR - http://www.scopus.com/inward/citedby.url?scp=85065406461&partnerID=8YFLogxK
M3 - Conference contribution
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
ER -