3D Bioprinting: from Benches to Translational Applications

Marcel Alexander Heinrich, Wanjun Liu, Andrea Jimenez, Jingzhou Yang, Ali Akpek, Xiao Liu, Qingmeng Pi, Xuan Mu, Ning Hu, Raymond Michel Schiffelers, Jai Prakash, Jingwei Xie, Yu Shrike Zhang

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Over the last decades, the fabrication of 3D tissues has become commonplace in tissue engineering and regenerative medicine. However, conventional 3D biofabrication techniques such as scaffolding, microengineering, and fiber and cell sheet engineering are limited in their capacity to fabricate complex tissue constructs with the required precision and controllability that is needed to replicate biologically relevant tissues. To this end, 3D bioprinting offers great versatility to fabricate biomimetic, volumetric tissues that are structurally and functionally relevant. It enables precise control of the composition, spatial distribution, and architecture of resulting constructs facilitating the recapitulation of the delicate shapes and structures of targeted organs and tissues. This Review systematically covers the history of bioprinting and the most recent advances in instrumentation and methods. It then focuses on the requirements for bioinks and cells to achieve optimal fabrication of biomimetic constructs. Next, emerging evolutions and future directions of bioprinting are discussed, such as freeform, high-resolution, multimaterial, and 4D bioprinting. Finally, the translational potential of bioprinting and bioprinted tissues of various categories are presented and the Review is concluded by exemplifying commercially available bioprinting platforms.

Original languageEnglish (US)
Article number1805510
JournalSmall
Volume15
Issue number23
DOIs
StatePublished - Jun 7 2019

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Keywords

  • 3D bioprinting
  • additive manufacturing
  • bioinks
  • regenerative medicine
  • tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)

Cite this

Heinrich, M. A., Liu, W., Jimenez, A., Yang, J., Akpek, A., Liu, X., Pi, Q., Mu, X., Hu, N., Schiffelers, R. M., Prakash, J., Xie, J., & Zhang, Y. S. (2019). 3D Bioprinting: from Benches to Translational Applications. Small, 15(23), [1805510]. https://doi.org/10.1002/smll.201805510