3-alkoxy-1,2-dioxolanes: Synthesis and evaluation as potential antimalarial agents

Charles E. Schiaffo, Matthias Rottman, Sergio Wittlin, Patrick H. Dussault

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A number of 3-alkoxy-1,2-dioxolanes exhibit promising levels of antimalarial activity against Plasmodium falciparum. A new route to the 1,2-dioxolane core is reported based on tandem peroxidation/cyclization of enones.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalACS Medicinal Chemistry Letters
Volume2
Issue number4
DOIs
StatePublished - Apr 14 2011

Fingerprint

Dioxolanes
Cyclization
Antimalarials
Plasmodium falciparum
formal glycol
alkoxyl radical

Keywords

  • 3-alkoxy-1,2-dioxolane
  • Malaria
  • dioxolane
  • peroxide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

3-alkoxy-1,2-dioxolanes : Synthesis and evaluation as potential antimalarial agents. / Schiaffo, Charles E.; Rottman, Matthias; Wittlin, Sergio; Dussault, Patrick H.

In: ACS Medicinal Chemistry Letters, Vol. 2, No. 4, 14.04.2011, p. 316-319.

Research output: Contribution to journalArticle

Schiaffo, Charles E. ; Rottman, Matthias ; Wittlin, Sergio ; Dussault, Patrick H. / 3-alkoxy-1,2-dioxolanes : Synthesis and evaluation as potential antimalarial agents. In: ACS Medicinal Chemistry Letters. 2011 ; Vol. 2, No. 4. pp. 316-319.
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