Abstract
1,25-Dihydroxyvitamin D can inhibit the proliferation of prostate cancer cells, but its clinical use is limited by hypercalcemia. We examined the effects of a “noncalcemic” vitamin D analogue, 1,25-Dihydroxy-16-ene-23-yne-cholecalciferol (16-23-D3), on the proliferation of human prostate cancer cells in a mouse model. Twenty-four athymic nude mice were inoculated with human prostate carcinoma cells from the PC-3 cell line. Twelve mice (experimental group) received injections of 1.6 μg of 16-23-D3 on alternate days over a 22-day period. Twelve mice (control group) received sham injections. Tumor volumes, pathologic findings, and terminal serum calcium levels were compared between groups. The relative increase in tumor volume was significantly lower in the experimental than in the control group in the first interval following treatment (P < 0.01). Mean tumor volumes in the experimental group were approximately 15% smaller than in the control group. Serum calcium levels did not differ between groups. 16-23-D3 showed modest antiproliferative effects on prostate cancer cells in this model without evidence of drug-induced hypercalcemia. These findings support the concept that vitamin D analogues can inhibit the proliferation of human prostate cancer cells in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 365-369 |
| Number of pages | 5 |
| Journal | Urology |
| Volume | 46 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1995 |
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ASJC Scopus subject areas
- Urology
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1,25-dihydroxy-16-ene-23-yne-vitamin d3 and prostate cancer cell proliferation in vivo. / Schwartz, Gary G.; Hill, Christopher C.; Oeler, Theresa A.; Becich, Michael J.; Bahnson, Robert R.
In: Urology, Vol. 46, No. 3, 01.01.1995, p. 365-369.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 1,25-dihydroxy-16-ene-23-yne-vitamin d3 and prostate cancer cell proliferation in vivo
AU - Schwartz, Gary G.
AU - Hill, Christopher C.
AU - Oeler, Theresa A.
AU - Becich, Michael J.
AU - Bahnson, Robert R.
PY - 1995/1/1
Y1 - 1995/1/1
N2 - 1,25-Dihydroxyvitamin D can inhibit the proliferation of prostate cancer cells, but its clinical use is limited by hypercalcemia. We examined the effects of a “noncalcemic” vitamin D analogue, 1,25-Dihydroxy-16-ene-23-yne-cholecalciferol (16-23-D3), on the proliferation of human prostate cancer cells in a mouse model. Twenty-four athymic nude mice were inoculated with human prostate carcinoma cells from the PC-3 cell line. Twelve mice (experimental group) received injections of 1.6 μg of 16-23-D3 on alternate days over a 22-day period. Twelve mice (control group) received sham injections. Tumor volumes, pathologic findings, and terminal serum calcium levels were compared between groups. The relative increase in tumor volume was significantly lower in the experimental than in the control group in the first interval following treatment (P < 0.01). Mean tumor volumes in the experimental group were approximately 15% smaller than in the control group. Serum calcium levels did not differ between groups. 16-23-D3 showed modest antiproliferative effects on prostate cancer cells in this model without evidence of drug-induced hypercalcemia. These findings support the concept that vitamin D analogues can inhibit the proliferation of human prostate cancer cells in vivo.
AB - 1,25-Dihydroxyvitamin D can inhibit the proliferation of prostate cancer cells, but its clinical use is limited by hypercalcemia. We examined the effects of a “noncalcemic” vitamin D analogue, 1,25-Dihydroxy-16-ene-23-yne-cholecalciferol (16-23-D3), on the proliferation of human prostate cancer cells in a mouse model. Twenty-four athymic nude mice were inoculated with human prostate carcinoma cells from the PC-3 cell line. Twelve mice (experimental group) received injections of 1.6 μg of 16-23-D3 on alternate days over a 22-day period. Twelve mice (control group) received sham injections. Tumor volumes, pathologic findings, and terminal serum calcium levels were compared between groups. The relative increase in tumor volume was significantly lower in the experimental than in the control group in the first interval following treatment (P < 0.01). Mean tumor volumes in the experimental group were approximately 15% smaller than in the control group. Serum calcium levels did not differ between groups. 16-23-D3 showed modest antiproliferative effects on prostate cancer cells in this model without evidence of drug-induced hypercalcemia. These findings support the concept that vitamin D analogues can inhibit the proliferation of human prostate cancer cells in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0028971107&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028971107&partnerID=8YFLogxK
U2 - 10.1016/S0090-4295(99)80221-0
DO - 10.1016/S0090-4295(99)80221-0
M3 - Article
C2 - 7660511
AN - SCOPUS:0028971107
VL - 46
SP - 365
EP - 369
JO - Urology
JF - Urology
SN - 0090-4295
IS - 3
ER -