δ-catenin regulates spine architecture via cadherin and PDZ-dependent interactions

Li Yuan, Eunju Seong, James L. Beuscher, Jyothi Arikkath

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The ability of neurons to maintain spine architecture and modulate it in response to synaptic activity is a crucial component of the cellular machinery that underlies information storage in pyramidal neurons of the hippocampus. Here we show a critical role for δ-catenin, a component of the cadherin-catenin cell adhesion complex, in regulating spine head width and length in pyramidal neurons of the hippocampus. The loss of Ctnnd2, the gene encoding δ-catenin, has been associated with the intellectual disability observed in the cri du chat syndrome, suggesting that the functional roles of δ-catenin are vital for neuronal integrity and higher order functions. We demonstrate that loss of δ-catenin in a mouse model or knockdown of δ-catenin in pyramidal neurons compromises spine head width and length, without altering spine dynamics. This is accompanied by a reduction in the levels of synaptic N-cadherin. The ability of δ-catenin to modulate spine architecture is critically dependent on its ability to interact with cadherin and PDZ domain-containing proteins. We propose that loss of δ-catenin during development perturbs synaptic architecture leading to developmental aberrations in neural circuit formation that contribute to the learning disabilities in a mouse model and humans with cri du chat syndrome.

Original languageEnglish (US)
Pages (from-to)10947-10957
Number of pages11
JournalJournal of Biological Chemistry
Volume290
Issue number17
DOIs
StatePublished - Apr 24 2015

Fingerprint

Catenins
Cadherins
Spine
Neurons
Aptitude
Pyramidal Cells
Cri-du-Chat Syndrome
Hippocampus
PDZ Domains
Gene encoding
Information Storage and Retrieval
Learning Disorders
Cell adhesion
Aberrations
Cell Adhesion
Intellectual Disability
Machinery
Data storage equipment
Networks (circuits)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

δ-catenin regulates spine architecture via cadherin and PDZ-dependent interactions. / Yuan, Li; Seong, Eunju; Beuscher, James L.; Arikkath, Jyothi.

In: Journal of Biological Chemistry, Vol. 290, No. 17, 24.04.2015, p. 10947-10957.

Research output: Contribution to journalArticle

Yuan, Li ; Seong, Eunju ; Beuscher, James L. ; Arikkath, Jyothi. / δ-catenin regulates spine architecture via cadherin and PDZ-dependent interactions. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 17. pp. 10947-10957.
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