γδ T Lymphocytes in Human Tuberculosis

Peter F. Barnes, Cara L. Grisso, John S. Abrams, Hamid Band, Thomas H. Rea, Robert L. Modlin

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

The manifestations of tuberculous infection reflect the immune response to infection. Most healthy tuberculin reactors develop protective immunity; tuberculous pleuritis reflects a resistant response manifest by mild disease, whereas advanced pulmonary and miliary tuberculosis reflect ineffective immunity. The role of γδ T cells was assessed in tuberculous infection by evaluating expansion of these cells from blood mononuclear cells after stimulation with Mycobacterium tuberculosis. After culture in vitro, the percentages of γδ+ cells were significantly greater in patients with protective and resistant immunity (tuberculin reactors, 25% ± 4%; tuberculous pleuritis, 30% ± 7%) than in those with ineffective immunity (advanced pulmonary tuberculosis, 9% ± 3%; miliary tuberculosis, 2% ± 1%). In leprosy, expansion of γδ+cells was greater in immunologically resistant tuberculoid patients (32% ± 4%) than in Mycobacterium leprae-unresponsive lepromatous patients (9% ± 2%). M. tuberculosis-reactive γδ T cell lines produced interferon-γ, granulocyte-macrophage colony-stimulating factor, interleukin-3, and tumor necrosis factor-a, cytokines that activate macrophages and may contribute to mycobacterial elimination. These findings suggest that γδ T cells contribute to immune resistance against M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)506-512
Number of pages7
JournalJournal of Infectious Diseases
Volume165
Issue number3
DOIs
StatePublished - Jan 1 1992

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Miliary Tuberculosis
Immunity
Tuberculosis
Mycobacterium tuberculosis
T-Lymphocytes
Pleurisy
Tuberculin
Pulmonary Tuberculosis
Infection
Mycobacterium leprae
Interleukin-3
Leprosy
Granulocyte-Macrophage Colony-Stimulating Factor
Interferons
Blood Cells
Tumor Necrosis Factor-alpha
Macrophages
Cytokines
Cell Line

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Barnes, P. F., Grisso, C. L., Abrams, J. S., Band, H., Rea, T. H., & Modlin, R. L. (1992). γδ T Lymphocytes in Human Tuberculosis. Journal of Infectious Diseases, 165(3), 506-512. https://doi.org/10.1093/infdis/165.3.506

γδ T Lymphocytes in Human Tuberculosis. / Barnes, Peter F.; Grisso, Cara L.; Abrams, John S.; Band, Hamid; Rea, Thomas H.; Modlin, Robert L.

In: Journal of Infectious Diseases, Vol. 165, No. 3, 01.01.1992, p. 506-512.

Research output: Contribution to journalArticle

Barnes, PF, Grisso, CL, Abrams, JS, Band, H, Rea, TH & Modlin, RL 1992, 'γδ T Lymphocytes in Human Tuberculosis', Journal of Infectious Diseases, vol. 165, no. 3, pp. 506-512. https://doi.org/10.1093/infdis/165.3.506
Barnes PF, Grisso CL, Abrams JS, Band H, Rea TH, Modlin RL. γδ T Lymphocytes in Human Tuberculosis. Journal of Infectious Diseases. 1992 Jan 1;165(3):506-512. https://doi.org/10.1093/infdis/165.3.506
Barnes, Peter F. ; Grisso, Cara L. ; Abrams, John S. ; Band, Hamid ; Rea, Thomas H. ; Modlin, Robert L. / γδ T Lymphocytes in Human Tuberculosis. In: Journal of Infectious Diseases. 1992 ; Vol. 165, No. 3. pp. 506-512.
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