REFLEX CONTROL OF THE CIRCULATION IN HEART FAILURE

Project: Research project

Description

The aim of the proposal is to study the control of the circulatory system by
neural pathways in normal and congestive heart failure animals. These studies
are divided into work with anesthetized and work with conscious, instrumented
animals. The extent to which cardiovascular afferent receptors are modified
both electrophysiologically as well as histologically during states of chronic
cardiac enlargement will be investigated initially. Alterations in the reflex
control of the circulatory system will be investigated in normal and heart
failure animals by stimulation of discrete receptor populations. The
mechanism(s) responsible for altered reflex control will be investigated by
observing such parameters as intracardiac pres ures, diameter, blood vessel
diameter, etc. Alterations in renal function and renal nerve activity will also
be investigated.
StatusFinished
Effective start/end date8/1/7811/30/86

Funding

  • National Institutes of Health

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Cardiovascular System
Reflex
Heart Failure
Kidney
Population

ASJC

  • Medicine(all)