LABORATORY CANCER RESEARCH CENTER

Project: Research project

Description

The specific aims of the Laboratory Cancer Research Center at the Eppley
Institute for Research in Cancer and Allied Diseases are to carry out
interdisciplinary research in: 1) cancer cause and prevention aimed at
determining the mechanisms of action of chemical carcinogens, including
the mechanisms of activation of carcinogens and their interactions with
DNA, the role of potential environmental carcinogens in human cancer, the
interaction of oncogenes and chemical carcinogens in tumor initiation and
promotion, and the role of dietary factors in causing and preventing
cancer; 2) molecular and cellular biology , including DNA replication,
mechanisms of gene transcription, the mechanisms of action of growth
factors and hormones, characterization of growth factor receptors and
their signal transduction mechanisms, the role of oncogene expression in
cellular differentiation, mechanisms of viral reproduction and oncogene
activation, and DNA-protein interactions; and 3) developmental
therapeutics, including characterization of tumor markers, isolation and
characterization of tumor-associated antigens, development of monoclonal
antibodies, development of antisense and triple helical-forming
oligonucleotides to inhibit cancer cell growth, synthesis of novel
antineoplastic agents, use of peripheral stem cells and cytokines in bone
marrow transplantation, and design of protocols for improved drug
delivery and pharmacokinetic analysis of anticancer agents. To achieve these specific aims we have assembled a group of 52 faculty
with expertise in chemistry, biochemistry, cell biology, molecular
biology, immunology, pathology, virology, pharmacology, toxicology,
nutrition, and clinical oncology. In support of this research we have
established core laboratory facilities in animal care, cell culture,
histology, molecular biology including 2-dimensional gel electrophoresis,
mass spectrometry, nuclear magnetic resonance spectrometry, computer
services including molecular modeling and DNA and protein data base
analysis, drug analysis and pharmacokinetics, microbial mutagenesis,
glassware washing, and safety. In addition, we have established a
Leukemia/Lymphoma Tissue Procurement Service that supports a region-wide
program for data collection and protocol standardization. The Core Grant
faculty also comprise the nucleus of our Cancer Biology Training Program
for the education and research training of predoctoral and postdoctoral
students.
StatusActive
Effective start/end date7/1/847/31/21

Funding

  • National Institutes of Health
  • National Institutes of Health
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  • National Institutes of Health: $1,493,508.00
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  • National Institutes of Health: $1,136,559.00
  • National Institutes of Health
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  • National Institutes of Health: $88,024.00
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  • National Institutes of Health: $1,450,000.00
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  • National Institutes of Health: $170,863.00
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  • National Institutes of Health: $33,154.00
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  • National Institutes of Health: $250,000.00
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  • National Institutes of Health: $1,504,111.00
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  • National Institutes of Health: $74,440.00
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Fingerprint

Neoplasms
Research
Tissue and Organ Procurement
Molecular Biology
Research Personnel
Carcinogens
Safety
Financial Management
Oncogenes
Organized Financing
Information Dissemination
Cell Biology
Clinical Trials
DNA
Biostatistics
Pathology
Histology
Advisory Committees
Cell Culture Techniques
Pharmacokinetics

ASJC

  • Medicine(all)