BREAST CANCER MUC-1 IN CELL ADHESION AND METASTASIS

Project: Research project

Description

The hypothesis of this application is that differential O-glycosylation of MUC-1 mucin contributes to the detachment of cancer cells from a primary cancer and mediates attachment at metastatic sites. The hypothesis will be assessed by three specific aims. The first will identify various forms of the MUC-1 mucin that interact with the matrix protein. The second specific aim will characterize the oligosaccharide and protein structure of MUC-1 mucin that interact with matrix proteins. The third specific aim will characterize the MUC-1 mucins that interact in breast cancer with normal human lung endothelial cells.
StatusActive
Effective start/end date2/3/98 → …

Funding

  • National Institutes of Health: $12,766.00

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Mucin-1
Cell Adhesion
Breast Neoplasms
Neoplasm Metastasis
Proteins
Oligosaccharides
Glycosylation
Neoplasms
Endothelial Cells
Lung

ASJC

  • Medicine(all)