Project: Research project


Our plans in this revised application for the Center for Neuroscience in
Schizophrenia (CNS) represent a natural outgrowth of the collaborative
interactions that exist within the large community of basic and clinical
neuroscientists on campus. Given the heterogeneity of the schizophrenic
syndrome and the lack of consensus regarding its pathogenesis, we
believe that a diverse and multidisciplinary approach is the most
appropriate conceptual perspective for relating neuroscience and
schizophrenia. Consequently, the scientific areas of basic and clinical
investigations proposed in this application deliberately include a wide
range of topics and approaches to the study of brain function in animal
and human subjects. The Center will consist of the Clinical Core; and
four major research programs. The Clinical Core will undertake the
recruitment, clinical assessment, management, maintenance, and follow-up
of clinical and normal subjects required for current and future studies,
including those associated with the Seed Money Program. It will, in
addition, conduct neuropsychological, autoimmune, sleep, cognitive, and
treatment investigations. The four key research programs proposed
encompass neurophysiological studies of the alterations in the network
properties of hippocampal neurons in rats, neuronanatomical studies of
the prefrontal cortex in monkeys , neurophysiological studies of
dopaminergic neurons and neurochemical studies of dopamine release in
rat forebrain and clinical in vivo NMR assessment of structural and
metabolic changes in the brains of schizophrenic patients. As might be
expected, certain common themes run through the four programs. For
example, a role for frontal cortical dysfunctions in the etiology of
schizophrenia is presumed in Programs 2, 3, and 4 and the biological
actions of typical and atypical neuroleptics are relevant to all four
programs. Our greatest hope and reason for investment in this venture
is in the participatory scientific and mutual educational activities
between basic neuroscientists and clinical investigators that we see in
a Center of this kind, and the emergence from such productive
collaborative interactions of new hypotheses and modes for approaching
these issues of joint concern, as well as the development of the next
generations of investigators who will be sufficiently will trained and
equipped to develop successful links between basic and clinical
neuroscience relevant to major mental disorders.
Effective start/end date4/1/906/30/09


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


Prefrontal Cortex
Pyramidal Cells
Oligonucleotide Array Sequence Analysis
In Situ Hybridization
Confocal Microscopy
Gene Expression
Messenger RNA