Xuejun Wang, PhD, MBBS

Professor

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 10198 Citations
  • 46 h-Index
19962019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1996 2019

Filter
Article
2013
6 Citations (Scopus)

Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

Lei, D., Li, F., Su, H., Liu, J., Wei, N. & Wang, X., Jul 1 2013, In : PloS one. 8, 7, e67793.

Research output: Contribution to journalArticle

proteasome endopeptidase complex
Proteasome Endopeptidase Complex
ubiquitin
Ubiquitin
Liver
56 Citations (Scopus)

Protein kinase G positively regulates proteasome-mediated degradation of misfolded proteins

Ranek, M. J., Terpstra, E. J. M., Li, J., Kass, D. A. & Wang, X., Jul 23 2013, In : Circulation. 128, 4, p. 365-376 12 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Proteasome Endopeptidase Complex
Proteolysis
Ubiquitin
Ubiquitinated Proteins
26 Citations (Scopus)

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice

Su, H., Li, J., Osinska, H., Li, F., Robbins, J., Liu, J., Wei, N. & Wang, X., Sep 1 2013, In : Circulation: Heart Failure. 6, 5, p. 1049-1057 9 p.

Research output: Contribution to journalArticle

Autophagy
Proteasome Endopeptidase Complex
Cardiac Myocytes
Proteolysis
Cullin Proteins
2012
61 Citations (Scopus)

Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in Mice

Tian, Z., Zheng, H., Li, J., Li, Y., Su, H. & Wang, X., Aug 17 2012, In : Circulation Research. 111, 5, p. 532-542 11 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Proteasome Endopeptidase Complex
Reperfusion Injury
Cardiac Myocytes
Myocardial Ischemia
53 Citations (Scopus)

L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro

Huang, H., Liu, N., Guo, H., Liao, S., Li, X., Yang, C., Liu, S., Song, W., Liu, C., Guan, L., Li, B., Xu, L., Zhang, C., Wang, X., Dou, Q. P. & Liu, J., Nov 5 2012, In : PloS one. 7, 11, e49062.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Carnitine
carnitine
Cell growth
cell growth
2011
114 Citations (Scopus)

Autophagy and p62 in cardiac proteinopathy

Zheng, Q., Su, H., Ranek, M. J. & Wang, X., Jul 22 2011, In : Circulation Research. 109, 3, p. 296-308 13 p.

Research output: Contribution to journalArticle

Desmin
Autophagy
Cardiac Myocytes
Cardiomyopathies
Muscle Cells
62 Citations (Scopus)

COP9 signalosome regulates autophagosome maturation

Su, H., Li, F., Ranek, M. J., Wei, N. & Wang, X., Nov 8 2011, In : Circulation. 124, 19, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Autophagy
Proteasome Endopeptidase Complex
Necrosis
Ubiquitin
11 Citations (Scopus)

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation

Lei, D., Li, F., Su, H., Tian, Z., Ye, B., Wei, N. & Wang, X., Feb 1 2011, In : Cell Death and Differentiation. 18, 2, p. 259-270 12 p.

Research output: Contribution to journalArticle

Hepatocytes
Liver
Cullin Proteins
Gene Knockout Techniques
Gene Targeting
117 Citations (Scopus)

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

Li, J., Horak, K. M., Su, H., Sanbe, A., Robbins, J. & Wang, X., Sep 1 2011, In : Journal of Clinical Investigation. 121, 9, p. 3689-3700 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Reperfusion Injury
Desmin
Cardiomyopathies
Myocardial Ischemia
89 Citations (Scopus)

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress

Li, J., Powell, S. R. & Wang, X., Mar 1 2011, In : FASEB Journal. 25, 3, p. 883-893 11 p.

Research output: Contribution to journalArticle

Activator Appliances
Oxidative stress
Proteasome Endopeptidase Complex
Oxidative Stress
Cardiac Myocytes
55 Citations (Scopus)

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice

Su, H., Li, J., Menon, S., Liu, J., Kumarapeli, A. R., Wei, N. & Wang, X., Jan 7 2011, In : Circulation Research. 108, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

Cullin Proteins
Dilated Cardiomyopathy
Proteasome Endopeptidase Complex
Ubiquitin
Cardiac Myocytes
48 Citations (Scopus)

Proteasome functional insufficiency in cardiac pathogenesis

Wang, X., Li, J., Zheng, H., Su, H. & Powell, S. R., Dec 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 6, p. 2207-2219 13 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Heart Diseases
Myocardial Reperfusion Injury
19 Citations (Scopus)

Sanggenon C decreases tumor cell viability associated with proteasome inhibition

Huang, H., Liu, N., Zhao, K., Zhu, C., Lu, X., Li, S., Lian, W., Zhou, P., Dong, X., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Lu, L., Li, X., Guan, L., Liu, C., Wang, X., Dou, Q. P. & 1 others, Liu, J., Jan 6 2011, In : Frontiers in Bioscience - Elite. 3 E, 4, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Tumors
Cell Survival
Cells
Neoplasms
86 Citations (Scopus)

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition

Lu, L., Qin, A., Huang, H., Zhou, P., Zhang, C., Liu, N., Li, S., Wen, G., Zhang, C., Dong, W., Wang, X., Dou, Q. P. & Liu, J., May 11 2011, In : European Journal of Pharmacology. 658, 2-3, p. 242-247 6 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Medicinal Plants
Anti-Inflammatory Agents
Macrophages
Lithospermum
2010
19 Citations (Scopus)

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

Zheng, H., Tang, M., Zheng, Q., Kumarapeli, A. R. K., Horak, K. M., Tian, Z. & Wang, X., Oct 19 2010, In : Journal of the American College of Cardiology. 56, 17, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

Doxycycline
Cardiac Myocytes
Desmin
Cardiomyopathies
Proteins
79 Citations (Scopus)

Physiological levels of ATP negatively regulate proteasome function

Huang, H., Zhang, X., Li, S., Liu, N., Lian, W., McDowell, E., Zhou, P., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Dong, X., Lu, L., Ma, N., Dong, W., Dou, Q. P., Wang, X. & Liu, J., Dec 1 2010, In : Cell Research. 20, 12, p. 1372-1385 14 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Adenosine Triphosphate
Chymotrypsin
Ubiquitin
Proteolysis
71 Citations (Scopus)

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

Tang, M., Li, J., Huang, W., Su, H., Liang, Q., Tian, Z., Horak, K. M., Molkentin, J. D. & Wang, X., Dec 1 2010, In : Cardiovascular research. 88, 3, p. 424-433 10 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Calcineurin
Proteasome Endopeptidase Complex
Cardiac Myocytes
Desmin
10 Citations (Scopus)

Protein quality control in protection against systolic overload cardiomyopathy: The long term role of small heat shock proteins

Kumarapeli, A. R. K., Horak, K. & Wang, X., Oct 8 2010, In : American Journal of Translational Research. 2, 4, p. 390-401 12 p.

Research output: Contribution to journalArticle

Small Heat-Shock Proteins
Cardiomyopathies
Quality Control
Quality control
Pressure
2009
126 Citations (Scopus)

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo

Yang, H., Zhou, P., Huang, H., Chen, D., Ma, N., Cui, Q. C., Shen, S., Dong, W., Zhang, X., Lian, W., Wang, X., Dou, Q. P. & Liu, J., May 15 2009, In : International Journal of Cancer. 124, 10, p. 2450-2459 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Cell Death
Leukemia P388
Neoplasms
Lithospermum
25 Citations (Scopus)

The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription

Su, H., Huang, W. & Wang, X., Mar 1 2009, In : International Journal of Biochemistry and Cell Biology. 41, 3, p. 615-624 10 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Transcription
Cullin Proteins
Cyclins
Phosphotransferases
2008
56 Citations (Scopus)
Ubiquitination
Proteasome Endopeptidase Complex
Ubiquitin
Doxorubicin
Proteolysis
106 Citations (Scopus)

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

Tydlacka, S., Wang, C. E., Wang, X., Li, S. & Li, X. J., Dec 3 2008, In : Journal of Neuroscience. 28, 49, p. 13285-13295 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Neuroglia
Neurons
Proteins
36 Citations (Scopus)

Upregulation of myocardial 11S-activated proteasome in experimental hyperglycemia

Powell, S. R., Samuel, S. M., Wang, P., Divald, A., Thirunavukkarasu, M., Koneru, S., Wang, X. & Maulik, N., Mar 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 618-621 4 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Hyperglycemia
Up-Regulation
Ubiquitin
Proteins
52 Citations (Scopus)

αb-crystallin suppresses pressure overload cardiac hypertrophy

Kumarapeli, A. R. K., Su, H., Huang, W., Tang, M., Zheng, H., Horak, K. M., Li, M. & Wang, X., Dec 5 2008, In : Circulation Research. 103, 12, p. 1473-1482 10 p.

Research output: Contribution to journalArticle

Crystallins
Cardiomegaly
Cardiac Myocytes
Constriction
Transcriptional Activation
2007
46 Citations (Scopus)

Cardiac-specific haploinsufficiency of β-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction

Qu, J., Zhou, J., Ping Yi, X., Dong, B., Zheng, H., Miller, L. M., Wang, X., Schneider, M. D. & Li, F., Sep 1 2007, In : Journal of Molecular and Cellular Cardiology. 43, 3, p. 319-326 8 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Catenins
Cardiomegaly
Constriction
Gene Expression
41 Citations (Scopus)

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury

Kobayashi, S., Mao, K., Zheng, H., Wang, X., Patterson, C., O'Connell, T. D. & Liang, Q., Jul 27 2007, In : Journal of Biological Chemistry. 282, 30, p. 21945-21952 8 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hyperglycemia
Wounds and Injuries
Proteins
Mannitol
56 Citations (Scopus)

Upregulation of γ-catenin compensates for the loss of β-catenin in adult cardiomyocytes

Zhou, J., Qu, J., Xian, P. Y., Graber, K., Huber, L., Wang, X., Gerdes, A. M. & Li, F., Jan 1 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 1, p. H270-H276

Research output: Contribution to journalArticle

Catenins
Cardiac Myocytes
Up-Regulation
Tamoxifen
Knockout Mice
2006
74 Citations (Scopus)
Desmin
Proteasome Endopeptidase Complex
Ubiquitin
Cardiac Myocytes
Proteins
120 Citations (Scopus)

Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts

Liu, J., Chen, Q., Huang, W., Horak, K. M., Zheng, H., Mestril, R. & Wang, X., Feb 1 2006, In : FASEB Journal. 20, 2, p. 362-364 3 p.

Research output: Contribution to journalArticle

Protein folding
Desmin
Protein Folding
Muscular Diseases
Proteasome Endopeptidase Complex
20 Citations (Scopus)

Nuclear compartmentalization of FAK and FRNK in cardiac myocytes

Xian, P. Y., Zhou, J., Huber, L., Qu, J., Wang, X., Gerdes, A. M. & Li, F., Jun 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 6, p. H2509-H2515

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Cardiac Myocytes
Serine
Phosphorylation
Protein Kinase C
2005
90 Citations (Scopus)

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

Kumarapeli, A. R. K., Horak, K. M., Glasford, J. W., Li, J., Chen, Q., Liu, J., Zheng, H. & Wang, X., Dec 1 2005, In : FASEB Journal. 19, 14, p. 2051-2053 3 p.

Research output: Contribution to journalArticle

Antineoplastic Antibiotics
Echocardiography
Biological Models
Deregulation
Fluorescence microscopy
120 Citations (Scopus)

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake

Chen, Q., Liu, J. B., Horak, K. M., Zheng, H., Kumarapeli, A. R. K., Li, J., Li, F., Gerdes, A. M., Wawrousek, E. F. & Wang, X., Nov 1 2005, In : Circulation Research. 97, 10, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

Amyloidosis
Proteasome Endopeptidase Complex
Cardiac Myocytes
Ubiquitin
Proteins
110 Citations (Scopus)

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction

Tang, Y. D., Kuzman, J. A., Said, S., Anderson, B. E., Wang, X. & Gerdes, A. M., Nov 1 2005, In : Circulation. 112, 20, p. 3122-3130 9 p.

Research output: Contribution to journalArticle

Propylthiouracil
Arterioles
Atrophy
Dilatation
Thyroid Gland
23 Citations (Scopus)

Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure

Xian, P. Y., Zhou, J., Baker, J., Wang, X., Gerdes, A. M. & Li, F., Jan 1 2005, In : Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 282, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinases
heart failure
hypertrophy
Hypertrophy
phosphotransferases (kinases)
39 Citations (Scopus)

Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy

Gard, J. J., Yamada, K., Green, K. G., Eloff, B. C., Rosenbaum, D. S., Wang, X., Robbins, J., Schuessler, R. B., Yamada, K. A. & Saffitz, J. E., Aug 15 2005, In : Cardiovascular research. 67, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

Desmin
Gap Junctions
Cardiomyopathies
Connexin 43
Proteins
2004
49 Citations (Scopus)

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes

Dong, X., Liu, J., Zheng, H., Glasford, J. W., Huang, W., Chen, Q. H., Harden, N. R., Li, F., Gerdes, A. M. & Wang, X., Sep 1 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 3 56-3, p. H1417-H1425

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Cardiac Myocytes
Green Fluorescent Proteins
Proteins
2003
1 Citation (Scopus)

Expression and distribution of desmosomal proteins in a transgenic mouse model of desmin-related cardiomyopathy

Huang, W., Ma, W. Z. & Wang, X. J., Jul 1 2003, In : Chinese Journal of Clinical Rehabilitation. 7, 15, p. 2152-2154 3 p.

Research output: Contribution to journalArticle

Desmin
Cardiomyopathies
Transgenic Mice
Desmoplakins
Proteins
31 Citations (Scopus)

Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium

Yi, X. P., Wang, X., Gerdes, A. M. & Li, F., Jun 1 2003, In : Hypertension. 41, 6, p. 1317-1323 7 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Myocardium
Serine
Cardiac Myocytes
Heart Ventricles
91 Citations (Scopus)

αB-Crystallin Modulates Protein Aggregation of Abnormal Desmin

Wang, X., Klevitsky, R., Huang, W., Glasford, J., Li, F. & Robbins, J., Nov 14 2003, In : Circulation Research. 93, 10, p. 998-1005 8 p.

Research output: Contribution to journalArticle

Crystallins
Desmin
Proteins
Heart Failure
Small Heat-Shock Proteins
2002
42 Citations (Scopus)

Desmin filaments and cardiac disease: Establishing causality

Wang, X., Osinska, H., Gerdes, A. M. & Robbins, J., Dec 2002, In : Journal of Cardiac Failure. 8, 6 SUPPL., p. S287-S292

Research output: Contribution to journalArticle

Desmin
Causality
Heart Diseases
Cardiomegaly
Dilatation
2001
229 Citations (Scopus)

Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice

Wang, X., Osinska, H., Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, T. & Robbins, J., Jul 6 2001, In : Circulation Research. 89, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Open Access
Crystallins
Desmin
Cardiomyopathies
Mutation
Cardiac Myocytes
58 Citations (Scopus)

Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy

Wu, G., Yussman, M. G., Barrett, T. J., Hahn, H. S., Osinska, H., Hilliard, G. M., Wang, X., Toyokawa, T., Yatani, A., Lynch, R. A., Robbins, J. & Dorn, G. W., Dec 7 2001, In : Circulation Research. 89, 12, p. 1130-1137 8 p.

Research output: Contribution to journalArticle

Open Access
rab GTP-Binding Proteins
Transport Vesicles
Cardiomegaly
Cardiomyopathies
Muscle Cells
159 Citations (Scopus)

Mouse model of desmin-related cardiomyopathy

Wang, X., Osinska, H., Dorn, G. W., Nieman, M., Lorenz, J. N., Gerdes, A. M., Witt, S., Kimball, T., Gulick, J. & Robbins, J., May 15 2001, In : Circulation. 103, 19, p. 2402-2407 6 p.

Research output: Contribution to journalArticle

Desmin
Cardiomyopathies
Mutation
Transgenic Mice
Up-Regulation
17 Citations (Scopus)

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

Yang, Q., Hewett, T. E., Klevitsky, R., Sanbe, A., Wang, X. & Robbins, J., Jun 21 2001, In : Cardiovascular research. 51, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Cyclic AMP-Dependent Protein Kinases
Transgenic Mice
Phosphorylation
Exercise
2000
37 Citations (Scopus)

In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy

Sanbe, A., Nelson, D., Gulick, J., Setser, E., Osinska, H., Wang, X., Hewett, T. E., Klevitsky, R., Hayes, E., Warshaw, D. M. & Robbins, J., Aug 18 2000, In : Circulation Research. 87, 4, p. 296-302 7 p.

Research output: Contribution to journalArticle

Familial Hypertrophic Cardiomyopathy
Myosin Light Chains
Myofibrils
Hypertrophic Cardiomyopathy
Hypertrophy
1999
71 Citations (Scopus)

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling

Wang, X., Faqian, L., Campbell, S. E. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 319-331 13 p.

Research output: Contribution to journalArticle

Cardiomegaly
Muscle Cells
Guinea Pigs
Heart Failure
Pressure
23 Citations (Scopus)

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling

Wang, X., Li, F. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 307-317 11 p.

Research output: Contribution to journalArticle

Cardiomegaly
Muscle Cells
Guinea Pigs
Heart Failure
Hemodynamics
86 Citations (Scopus)

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling

Wang, X. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 333-343 11 p.

Research output: Contribution to journalArticle

Cardiomegaly
Muscle Cells
Catenins
Guinea Pigs
Heart Failure
125 Citations (Scopus)

The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function

Milner, D. J., Taffet, G. E., Wang, X., Pham, T., Tamura, T., Hartley, C., Gerdes, M. A. & Capetanaki, Y., Nov 1999, In : Journal of Molecular and Cellular Cardiology. 31, 11, p. 2063-2076 14 p.

Research output: Contribution to journalArticle

Desmin
Cardiomegaly
Cardiac Myocytes
Dilatation
Muscle Cells
1997
55 Citations (Scopus)

Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation

Li, F., Wang, X. & Gerdes, A. M., Jun 1997, In : Journal of Molecular and Cellular Cardiology. 29, 6, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Actinin
Cytoplasm
Vinculin
Muscle Cells