Xuejun Wang, PhD, MBBS

Professor

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 10083 Citations
  • 46 h-Index
19962019
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Research Output 1996 2019

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Article
2019
1 Citation (Scopus)

Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling

Liu, N., Guo, Z., Xia, X., Liao, Y., Zhang, F., Huang, C., Liu, Y., Deng, X., Jiang, L., Wang, X., Liu, J. & Huang, H., Mar 5 2019, In : European Journal of Pharmacology. 846, p. 1-11 11 p.

Research output: Contribution to journalArticle

Auranofin
Androgen Receptors
Prostatic Neoplasms
Androgens
Thioredoxin-Disulfide Reductase
1 Citation (Scopus)

Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer

Liao, Y., Guo, Z., Xia, X., Liu, Y., Huang, C., Jiang, L., Wang, X., Liu, J. & Huang, H., Apr 11 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 157.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor Receptor
Prostatic Neoplasms
Castration
Apoptosis
Ubiquitin
1 Citation (Scopus)

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

Xia, X., Huang, C., Liao, Y., Liu, Y., He, J., Guo, Z., Jiang, L., Wang, X., Liu, J. & Huang, H., May 24 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 220.

Research output: Contribution to journalArticle

Open Access
Androgen Receptors
Breast Neoplasms
Small Interfering RNA
Androgen Receptor Antagonists
Apoptosis
2 Citations (Scopus)

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

Zhang, H., Pan, B., Wu, P., Parajuli, N., Rekhter, M. D., Goldberg, A. L. & Wang, X., Jan 1 2019, In : Science Advances. 5, 5, aaw5870.

Research output: Contribution to journalArticle

Open Access
ejection
degradation
proteins
mice
heart diseases

Synergistic effects of gefitinib and thalidomide treatment on EGFR-TKI-sensitive and -resistant NSCLC

Xia, X., Liu, Y., Liao, Y., Guo, Z., Huang, C., Zhang, F., Jiang, L., Wang, X., Liu, J. & Huang, H., Aug 5 2019, In : European Journal of Pharmacology. 856, 172409.

Research output: Contribution to journalArticle

Thalidomide
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Drug Resistance
2018
3 Citations (Scopus)

Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase

Chen, X., Wu, J., Yang, Q., Zhang, X., Zhang, P., Liao, S., He, Z., Wang, X., Zhao, C. & Liu, J., Feb 1 2018, In : BioMetals. 31, 1, p. 29-43 15 p.

Research output: Contribution to journalArticle

proteasome endopeptidase complex
Cadmium
Proteasome Endopeptidase Complex
Tumors
cadmium
6 Citations (Scopus)

Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury

Hu, C., Tian, Y., Xu, H., Pan, B., Terpstra, E. M., Wu, P., Wang, H., Li, F., Liu, J. & Wang, X., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5294-5306 13 p.

Research output: Contribution to journalArticle

Myocardial Reperfusion Injury
Ubiquitination
Proteasome Endopeptidase Complex
Ubiquitin
Reperfusion Injury
5 Citations (Scopus)

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Chen, X., Yang, Q., Chen, J., Zhang, P., Huang, Q., Zhang, X., Yang, L., Xu, D., Zhao, C., Wang, X. & Liu, J., Sep 1 2018, In : Cellular Physiology and Biochemistry. 49, 2, p. 780-797 18 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Silver
Non-Small Cell Lung Carcinoma
Apoptosis
Ubiquitin
9 Citations (Scopus)

Targeting proteasome-associated deubiquitinases as a novel strategy for the treatment of estrogen receptor-positive breast cancer

Xia, X., Liao, Y., Guo, Z., Li, Y., Jiang, L., Zhang, F., Huang, C., Liu, Y., Wang, X., Liu, N., Liu, J. & Huang, H., Sep 1 2018, In : Oncogenesis. 7, 9, 75.

Research output: Contribution to journalArticle

Open Access
Proteasome Endopeptidase Complex
Estrogen Receptors
Breast Neoplasms
Platinum
Endoplasmic Reticulum Stress
2 Citations (Scopus)

UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

Sane, S., Hafner, A., Srinivasan, R., Masood, D., Slunecka, J. L., Noldner, C. J., Hanson, A. D., Kruisselbrink, T., Wang, X., Wang, Y., Yin, J. & Rezvani, K., Oct 2018, In : Molecular Oncology. 12, 10, p. 1753-1777 25 p.

Research output: Contribution to journalArticle

Oncogene Proteins
Neoplasms
Proteins
Colorectal Neoplasms
Ubiquitination
2017
8 Citations (Scopus)

Activation of Yap1/Taz signaling in ischemic heart disease and dilated cardiomyopathy

Hou, N., Wen, Y., Yuan, X., Xu, H., Wang, X., Li, F. & Ye, B., Dec 2017, In : Experimental and Molecular Pathology. 103, 3, p. 267-275 9 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Myocardial Ischemia
Heart Diseases
Chemical activation
Desmin
13 Citations (Scopus)

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers

Cai, J., Xia, X., Liao, Y., Liu, N., Guo, Z., Chen, J., Yang, L., Long, H., Yang, Q., Zhang, X., Xiao, L., Wang, X., Huang, H. & Liu, J., Jan 1 2017, In : Oncotarget. 8, 38, p. 63232-63246 15 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Apoptosis
Proteasome Endopeptidase Complex
Reactive Oxygen Species
10 Citations (Scopus)

Bilirubin neurotoxicity is associated with proteasome inhibition

Huang, H., Guo, M., Liu, N., Zhao, C., Chen, H., Wang, X., Liao, S., Zhou, P., Liao, Y., Chen, X., Lan, X., Chen, J., Xu, D., Li, X., Shi, X., Yu, L., Nie, Y., Wang, X., Zhang, C. E. & Liu, J., Jun 15 2017, In : Cell Death and Disease. 8, 6, e2877.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Bilirubin
Ubiquitinated Proteins
Peptide Hydrolases
Hyperbilirubinemia
13 Citations (Scopus)

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy

Li, J., Ma, W., Yue, G., Tang, Y., Kim, I. M., Weintraub, N. L., Wang, X. & Su, H., Jan 1 2017, In : Journal of Molecular and Cellular Cardiology. 102, p. 53-60 8 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Proteasome Endopeptidase Complex
Ubiquitin
Experimental Diabetes Mellitus
Proteins
12 Citations (Scopus)

Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer

Xiao, L., Lan, X., Shi, X., Zhao, K., Wang, D., Wang, X., Li, F., Huang, H. & Liu, J., May 18 2017, In : Cell death & disease. 8, 5, p. e2803

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cisplatin
Therapeutics
Health Services Needs and Demand
Cytotoxins
5 Citations (Scopus)

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells

Chen, X., Zhang, X., Chen, J., Yang, Q., Yang, L., Xu, D., Zhang, P., Wang, X. & Liu, J., Nov 15 2017, In : European Journal of Pharmacology. 815, p. 147-155 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Copper
Cell Death
K562 Cells
Neoplasms
1 Citation (Scopus)

Murine myocardial transcriptome analysis reveals a critical role of COPS8 in the gene expression of cullin-RING ligase substrate receptors and redox and vesicle trafficking pathways

Abdullah, A., Eyster, K. M., Bjordahl, T., Xiao, P., Zeng, E. & Wang, X., Aug 17 2017, In : Frontiers in Physiology. 8, AUG, 594.

Research output: Contribution to journalArticle

Cullin Proteins
Gene Expression Profiling
Ligases
Oxidation-Reduction
Gene Expression
12 Citations (Scopus)

Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

Wu, P., Yuan, X., Li, F., Zhang, J., Zhu, W., Wei, M., Li, J. & Wang, X., Jul 1 2017, In : Circulation: Heart Failure. 10, 7, e004044.

Research output: Contribution to journalArticle

Cathepsin D
Myocardial Ischemia
Up-Regulation
Heart Failure
Myocardial Infarction
5 Citations (Scopus)

Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

Lan, X., Zhao, C., Chen, X., Zhang, P., Zang, D., Wu, J., Chen, J., Long, H., Yang, L., Huang, H., Wang, X., Shi, X. & Liu, J., Jul 6 2017, In : Cell Death and Disease. 8, 7, e2913.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Caspases
Platinum
Down-Regulation
34 Citations (Scopus)

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

Liao, Y., Liu, N., Hua, X., Cai, J., Xia, X., Wang, X., Huang, H. & Liu, J., Feb 2 2017, In : Cell Death and Disease. 8, 2, e2585.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Androgen Receptors
Proteasome Endopeptidase Complex
Prostatic Neoplasms
Cell Cycle Resting Phase
7 Citations (Scopus)

Repurposing an antidandruff agent to treating cancer: Zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases

Zhao, C., Chen, X., Yang, C., Zang, D., Lan, X., Liao, S., Zhang, P., Wu, J., Li, X., Liu, N., Liao, Y., Huang, H., Shi, X., Jiang, L., Liu, X., Ping Dou, Q., Wang, X. & Liu, J., Jan 1 2017, In : Oncotarget. 8, 8, p. 13942-13956 15 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Growth
Ubiquitin
Neoplasms
Multiple Myeloma
13 Citations (Scopus)

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux

Pan, B., Zhang, H., Cui, T. & Wang, X., Dec 2017, In : Journal of Molecular and Cellular Cardiology. 113, p. 51-62 12 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Autophagy
Ubiquitinated Proteins
Messenger RNA
Crystallins
2016
8 Citations (Scopus)

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment

Jiang, L., Zang, D., Yi, S., Li, X., Yang, C., Dong, X., Zhao, C., Lan, X., Chen, X., Liu, S., Liu, N., Huang, H., Shi, X., Wang, X. & Liu, J., Feb 22 2016, In : Scientific reports. 6, 21565.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
MicroRNAs
Endoplasmic Reticulum Stress
Cell Survival
Neoplasms
25 Citations (Scopus)

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

Zhao, C., Chen, X., Zang, D., Lan, X., Liao, S., Yang, C., Zhang, P., Wu, J., Li, X., Liu, N., Liao, Y., Huang, H., Shi, X., Jiang, L., Liu, X., He, Z., Dou, Q. P., Wang, X. & Liu, J., Nov 10 2016, In : Oncogene. 35, 45, p. 5916-5927 12 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Nickel
Ubiquitin
Neoplasms
Therapeutics
8 Citations (Scopus)

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors

Zhang, L., Hapon, M. B., Goyeneche, A. A., Srinivasan, R., Gamarra-Luques, C. D., Callegari, E. A., Drappeau, D. D., Terpstra, E. J., Pan, B., Knapp, J. R., Chien, J., Wang, X., Eyster, K. M. & Telleria, C. M., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1099-1117 19 p.

Research output: Contribution to journalArticle

Mifepristone
Protein Biosynthesis
Lysosomes
Ovarian Neoplasms
Proteins
6 Citations (Scopus)

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Lan, X., Zhao, C., Chen, X., Zhang, P., Zang, D., Wu, J., Chen, J., Long, H., Yang, L., Huang, H., Carter, B. Z., Wang, X., Shi, X. & Liu, J., Nov 25 2016, In : Journal of Hematology and Oncology. 9, 1, 129.

Research output: Contribution to journalArticle

Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Nickel
Apoptosis
Proteasome Endopeptidase Complex
23 Citations (Scopus)

Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy Insufficiency

Qin, Q., Qu, C., Niu, T., Zang, H., Qi, L., Lyu, L., Wang, X., Nagarkatti, M., Nagarkatti, P., Janicki, J. S., Wang, X. L. & Cui, T., Jan 1 2016, In : Hypertension. 67, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

Autophagy
Angiotensinogen
Thoracic Aorta
Constriction
Cardiac Myocytes
4 Citations (Scopus)

Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated Protein quality control in cardiomyocytes

Cui, T., Lai, Y., Janicki, J. S. & Wang, X., Jan 1 2016, In : Frontiers in Bioscience - Landmark. 21, 1, p. 192-202 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Quality Control
Quality control
Lysosomes
Proteins
18 Citations (Scopus)

Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy

Zhao, C., Chen, X., Zang, D., Lan, X., Liao, S., Yang, C., Zhang, P., Wu, J., Li, X., Liu, N., Liao, Y., Huang, H., Shi, X., Jiang, L., Liu, X., He, Z., Wang, X. & Liu, J., Sep 15 2016, In : Biochemical Pharmacology. 116, p. 22-38 17 p.

Research output: Contribution to journalArticle

Platinum Compounds
Platinum
Cisplatin
Proteasome Endopeptidase Complex
Neoplasms
18 Citations (Scopus)

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure

Hou, N., Ye, B., Li, X., Margulies, K. B., Xu, H., Wang, X. & Li, F., Jun 1 2016, In : Circulation: Heart Failure. 9, 6, e003010.

Research output: Contribution to journalArticle

T Cell Transcription Factor 1
Catenins
Up-Regulation
Heart Failure
Cardiac Myocytes
26 Citations (Scopus)

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

Huang, H., Liao, Y., Liu, N., Hua, X., Cai, J., Yang, C., Long, H., Zhao, C., Chen, X., Lan, X., Zang, D., Wu, J., Li, X., Shi, X., Wang, X. & Liu, J., Jan 1 2016, In : Oncotarget. 7, 3, p. 2796-2808 13 p.

Research output: Contribution to journalArticle

Auranofin
Disulfiram
Aldehyde Dehydrogenase
Pharmaceutical Preparations
Neoplasms
2015
9 Citations (Scopus)

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac Proteotoxicity

Su, H., Li, J., Zhang, H., Ma, W., Wei, N., Liu, J. & Wang, X., Nov 6 2015, In : Circulation Research. 117, 11, p. 956-966 11 p.

Research output: Contribution to journalArticle

Cullin Proteins
Ligases
Ubiquitination
Proteins
Proteolysis
13 Citations (Scopus)

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

Shi, X., Lan, X., Chen, X., Zhao, C., Li, X., Liu, S., Huang, H., Liu, N., Zang, D., Liao, Y., Zhang, P., Wang, X. & Liu, J., Apr 13 2015, In : Scientific reports. 5, 9694.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Proteasome Endopeptidase Complex
B-Lymphocytes
Apoptosis
Phase II Clinical Trials
12 Citations (Scopus)

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

Ranek, M. J., Zheng, H., Huang, W., Kumarapeli, A. R., Li, J., Liu, J. & Wang, X., Aug 1 2015, In : Journal of Molecular and Cellular Cardiology. 85, p. 273-281 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Cardiac Myocytes
Heart Failure
Ubiquitin
Constriction
12 Citations (Scopus)

NEDD8 Ultimate Buster 1 Long (NUB1L) protein suppresses atypical neddylation and promotes the proteasomal degradation of misfolded proteins

Li, J., Ma, W., Li, H., Hou, N., Wang, X., Kim, I. M., Li, F. & Su, H., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23850-23862 13 p.

Research output: Contribution to journalArticle

Proteolysis
Cardiac Myocytes
Degradation
Ubiquitins
Ubiquitinated Proteins
2014
39 Citations (Scopus)

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

Liu, N., Liu, C., Li, X., Liao, S., Song, W., Yang, C., Zhao, C., Huang, H., Guan, L., Zhang, P., Liu, S., Hua, X., Chen, X., Zhou, P., Lan, X., Yi, S., Wang, S., Wang, X., Dou, Q. P. & Liu, J., Jun 10 2014, In : Scientific reports. 4, 5240.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteasome Endopeptidase Complex
Peptide Hydrolases
Growth
Neoplasms
41 Citations (Scopus)

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Chen, X., Shi, X., Zhao, C., Li, X., Lan, X., Liu, S., Huang, H., Liu, N., Liao, S., Zang, D., Song, W., Liu, Q., Carter, B. Z., Ping Dou, Q., Wang, X. & Liu, J., Jan 1 2014, In : Oncotarget. 5, 19, p. 9118-9132 15 p.

Research output: Contribution to journalArticle

Open Access
Auranofin
Antirheumatic Agents
Myeloid Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Apoptosis
20 Citations (Scopus)

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

Tian, Z., Wang, C., Hu, C., Tian, Y., Liu, J. & Wang, X., Jun 24 2014, In : PloS one. 9, 6, e100715.

Research output: Contribution to journalArticle

proteasome endopeptidase complex
Proteasome Endopeptidase Complex
ubiquitin
Ubiquitin
Cardiac Myocytes
70 Citations (Scopus)

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Liu, N., Li, X., Huang, H., Zhao, C., Liao, S., Yang, C., Liu, S., Song, W., Lu, X., Lan, X., Chen, X., Yi, S., Xu, L., Jiang, L., Zhao, C., Dong, X., Zhou, P., Li, S., Wang, S., Shi, X. & 3 others, Dou, P. Q., Wang, X. & Liu, J., 2014, In : Oncotarget. 5, 14, p. 5453-5471 19 p.

Research output: Contribution to journalArticle

Open Access
Auranofin
Antirheumatic Agents
Proteasome Endopeptidase Complex
Growth
Neoplasms
73 Citations (Scopus)

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent bcr-abl downregulation AC

Shi, X., Chen, X., Li, X., Lan, X., Zhao, C., Liu, S., Huang, H., Liu, N., Liao, S., Song, W., Zhou, P., Wang, S., Xu, L., Wang, X., Dou, Q. P. & Liu, J., Jan 1 2014, In : Clinical Cancer Research. 20, 1, p. 151-163 13 p.

Research output: Contribution to journalArticle

Myeloid Cells
Proteasome Endopeptidase Complex
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Caspases
Down-Regulation
71 Citations (Scopus)

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

Kwong, J. Q., Davis, J., Baines, C. P., Sargent, M. A., Karch, J., Wang, X., Huang, T. & Molkentin, J. D., Aug 2014, In : Cell Death and Differentiation. 21, 8, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

Phosphate Transport Proteins
Cardiomyopathies
Cell Death
Proteins
Gene Deletion
9 Citations (Scopus)

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Ranek, M. J., Kost, C. K., Hu, C., Martin, D. S. & Wang, X., Apr 2014, In : Journal of Molecular and Cellular Cardiology. 69, p. 43-51 9 p.

Research output: Contribution to journalArticle

Cyclic GMP-Dependent Protein Kinases
Muscarinic Receptors
Proteasome Endopeptidase Complex
Proteolysis
Peptide Hydrolases
43 Citations (Scopus)

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., May 2014, In : Journal of Neurochemistry. 129, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

Huntington Disease
Proteasome Endopeptidase Complex
Ubiquitin
Degradation
Brain
25 Citations (Scopus)

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

Gupta, M. K., Gulick, J., Liu, R., Wang, X., Molkentin, J. D. & Robbins, J., Jan 1 2014, In : Circulation Research. 115, 8, p. 721-729 9 p.

Research output: Contribution to journalArticle

Ubiquitin-Conjugating Enzymes
Cardiac Myocytes
Quality Control
Ubiquitin
Proteasome Endopeptidase Complex
13 Citations (Scopus)

The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., Apr 2014, In : Cellular and molecular neurobiology. 34, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Alzheimer Disease
Ubiquitin
Brain
Amyloid Plaques
32 Citations (Scopus)

Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice

Liu, Y., Lü, L., Hettinger, C. L., Dong, G., Zhang, D., Rezvani, K., Wang, X. & Wang, H., Feb 25 2014, In : Journal of Neuroscience. 34, 8, p. 2813-2821 9 p.

Research output: Contribution to journalArticle

Oxidative Stress
Stroke
Transgenic Mice
Wounds and Injuries
Proteasome Endopeptidase Complex
2013
23 Citations (Scopus)

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

Rajagopalan, V., Zhao, M., Reddy, S., Fajardo, G., Wang, X., Dewey, S., Gomes, A. V. & Bernstein, D., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H551-H562

Research output: Contribution to journalArticle

Right Ventricular Hypertrophy
Proteasome Endopeptidase Complex
Ubiquitin
Hypertrophy
Constriction
14 Citations (Scopus)

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats.

Li, S., Wang, X., Li, Y., Kost, C. K. & Martin, D. S., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

Open Access
Proteasome Inhibitors
angiotensin II
proteasome endopeptidase complex
Angiotensin II
hypertension
8 Citations (Scopus)

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

Liu, C., Guo, L. Q., Menon, S., Jin, D., Pick, E., Wang, X., Deng, X. W. & Wei, N., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

G1 Phase
Fibroblasts
Cells
Cell Cycle
Cell Aging
63 Citations (Scopus)

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Li, X., Liu, S., Huang, H., Liu, N., Zhao, C., Liao, S., Yang, C., Liu, Y., Zhao, C., Li, S., Lu, X., Liu, C., Guan, L., Zhao, K., Shi, X., Song, W., Zhou, P., Dong, X., Guo, H., Wen, G. & 9 others, Zhang, C., Jiang, L., Ma, N., Li, B., Wang, S., Tan, H., Wang, X., Dou, Q. P. & Liu, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 211-222 12 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteasome Endopeptidase Complex
Tissue
Tumors
Cytochrome P-450 CYP2E1